{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Molnar MZ"],"funding":["National Kidney Foundation","NIDDK NIH HHS","NIAID NIH HHS","National Institutes of Health","Merck Sharp and Dohme"],"pagination":["599-609"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8968853"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["22(2)"],"pubmed_abstract":["Kidney transplantation (KT) from deceased donors with hepatitis C virus (HCV) into HCV-negative recipients has become more common. However, the risk of complications such as BK polyomavirus (BKPyV) remains unknown. We assembled a retrospective cohort at four centers. We matched recipients of HCV-viremic kidneys to highly similar recipients of HCV-aviremic kidneys on established risk factors for BKPyV. To limit bias, matches were within the same center. The primary outcome was BKPyV viremia ≥1000 copies/ml or biopsy-proven BKPyV nephropathy; a secondary outcome was BKPyV viremia ≥10 000 copies/ml or nephropathy. Outcomes were analyzed using weighted and stratified Cox regression. The median days to peak BKPyV viremia level was 119 (IQR 87-182). HCV-viremic KT was not associated with increas"],"journal":["American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons"],"pubmed_title":["Association of donor hepatitis C virus infection status and risk of BK polyomavirus viremia after kidney transplantation."],"pmcid":["PMC8968853"],"funding_grant_id":["K24AI146137","R01DK070869","R01 DK070869","K24 AI146137"],"pubmed_authors":["Shah M","Molnar MZ","Blumberg E","Chung RT","Schaubel DE","Sise ME","Bhalla A","Bloom RD","Azhar A","Trofe-Clark J","Elias N","Potluri VS","Binari LA","Reese PP","Talwar M","Forbes RC","Sawinski D","Besharatian B","Concepcion BP","Strohbehn IA","Balaraman V","Shaffer D","Goldberg DS","Eason JD"],"additional_accession":[]},"is_claimable":false,"name":"Association of donor hepatitis C virus infection status and risk of BK polyomavirus viremia after kidney transplantation.","description":"Kidney transplantation (KT) from deceased donors with hepatitis C virus (HCV) into HCV-negative recipients has become more common. However, the risk of complications such as BK polyomavirus (BKPyV) remains unknown. We assembled a retrospective cohort at four centers. We matched recipients of HCV-viremic kidneys to highly similar recipients of HCV-aviremic kidneys on established risk factors for BKPyV. To limit bias, matches were within the same center. The primary outcome was BKPyV viremia ≥1000 copies/ml or biopsy-proven BKPyV nephropathy; a secondary outcome was BKPyV viremia ≥10 000 copies/ml or nephropathy. Outcomes were analyzed using weighted and stratified Cox regression. The median days to peak BKPyV viremia level was 119 (IQR 87-182). HCV-viremic KT was not associated with increas","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Feb","modification":"2025-04-05T09:05:27.521Z","creation":"2025-04-05T09:05:27.521Z"},"accession":"S-EPMC8968853","cross_references":{"pubmed":["34613666"],"doi":["10.1111/ajt.16834"]}}