{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wang Y"],"funding":["NIGMS NIH HHS"],"pagination":["1216-1224"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969080"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["51(3)"],"pubmed_abstract":["Herein we report a new series of bifunctional chelators (BFCs) with high affinity for amyloid β aggregates, strong binding affinity towards Cu(II), and favorable lipophilicity for potential blood-brain barrier (BBB) penetration. The alkyl carboxylate ester pendant arms show high binding affinity towards Cu(II). The BFCs form stable <sup>64</sup>Cu-radiolabeled complexes and exhibit favorable partition coefficient (log <i>D</i>) values of 0.75-0.95. Among the five compounds tested, 64Cu-YW-1 and 64Cu-YW-13 complexes exhibit significant staining of amyloid plaques in <i>ex vivo</i> autoradiography studies."],"journal":["Dalton transactions (Cambridge, England : 2003)"],"pubmed_title":["2-(4-Hydroxyphenyl)benzothiazole dicarboxylate ester TACN chelators for <sup>64</sup>Cu PET imaging in Alzheimer's disease."],"pmcid":["PMC8969080"],"funding_grant_id":["R01 GM114588"],"pubmed_authors":["Rogers BE","Mirica LM","Cho HJ","Wang Y","Bandara N","Huynh TT"],"additional_accession":[]},"is_claimable":false,"name":"2-(4-Hydroxyphenyl)benzothiazole dicarboxylate ester TACN chelators for <sup>64</sup>Cu PET imaging in Alzheimer's disease.","description":"Herein we report a new series of bifunctional chelators (BFCs) with high affinity for amyloid β aggregates, strong binding affinity towards Cu(II), and favorable lipophilicity for potential blood-brain barrier (BBB) penetration. The alkyl carboxylate ester pendant arms show high binding affinity towards Cu(II). The BFCs form stable <sup>64</sup>Cu-radiolabeled complexes and exhibit favorable partition coefficient (log <i>D</i>) values of 0.75-0.95. Among the five compounds tested, 64Cu-YW-1 and 64Cu-YW-13 complexes exhibit significant staining of amyloid plaques in <i>ex vivo</i> autoradiography studies.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-19T12:43:37.163Z","creation":"2025-04-19T12:43:37.163Z"},"accession":"S-EPMC8969080","cross_references":{"pubmed":["34951428"],"doi":["10.1039/d1dt02767k"]}}