biostudies-literatureZhao ZNatural Science Foundation of Hunan Province, ChinaNational Natural Science Foundation of China93https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969309biostudies-literatureUnknown22(1)<h4>Background</h4>Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have a good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order to explore the therapeutic mechanism of SND, we combined with 16S rRNA gene sequencing to analyze the composition of gut microflora in rats with HF.<h4>Material and methods</h4>Twenty Sprague-Dawley (SD) rats were divided into four groups (n = 5): normal group, model group, SND treatment group (SNT group), and metoprolol (Met) treatment group (Meto group). All the rats except the normal group were intraperitoneally injected with doxorubicin (concentration 2 mg/mL, dose 0.15 mL/100 g) once a week to induce HF. After successfully modeling, SND and Met were gavaged to rats, respectively. AfterBMC complementary medicine and therapiesBacterial diversity in the intestinal mucosa of heart failure rats treated with Sini Decoction.PMC8969309817742082020JJ5408Cao LLiu JHu YHu ZZhang XDong ZZhao ZLi LfalseBacterial diversity in the intestinal mucosa of heart failure rats treated with Sini Decoction.<h4>Background</h4>Sini Decoction (SND), a classic Chinese medicine prescription, has been proved to have a good effect on heart failure (HF), whereas its underlying mechanism is still unclear. In order to explore the therapeutic mechanism of SND, we combined with 16S rRNA gene sequencing to analyze the composition of gut microflora in rats with HF.<h4>Material and methods</h4>Twenty Sprague-Dawley (SD) rats were divided into four groups (n = 5): normal group, model group, SND treatment group (SNT group), and metoprolol (Met) treatment group (Meto group). All the rats except the normal group were intraperitoneally injected with doxorubicin (concentration 2 mg/mL, dose 0.15 mL/100 g) once a week to induce HF. After successfully modeling, SND and Met were gavaged to rats, respectively. After2022-01-01T00:00:00Z2022 Mar2026-06-18T05:44:05.796Z2025-04-06T14:50:49.135ZS-EPMC89693093535445310.1186/s12906-022-03575-4