{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Liu C"],"pubmed_abstract":["CG258 is the dominant carbapenemase-producing <i>Klebsiella pneumoniae</i> clone worldwide and treatment of infections caused by this clone relies largely on the last-line antibiotics, colistin, and tigecycline. However, the emergence and global dissemination of <i>mcr</i> and <i>tmexCD1</i>-<i>toprJ1</i> genes have significantly compromised their clinical applications. CG258 <i>K. pneumoniae</i> carrying both <i>mcr</i> and <i>tmexCD1</i>-<i>toprJ1</i> have not been reported. A colistin-resistant strain T698-1 belonging to ST1326, a member of CG258, was isolated from the intestinal sample of a patient and characterized by the antimicrobial susceptibility testing, conjugation assay, WGS and bioinformatics analysis. It was resistant to colistin, tetracycline, aminoglycoside, fluoroqinolone,"],"journal":["Frontiers in microbiology"],"pagination":["800993"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969419"],"repository":["biostudies-literature"],"pubmed_title":["Emergence of an ST1326 (CG258) Multi-Drug Resistant <i>Klebsiella pneumoniae</i> Co-harboring <i>mcr-8.2</i>, ESBL Genes, and the Resistance-Nodulation-Division Efflux Pump Gene Cluster <i>tmexCD1-toprJ1</i> in China."],"pmcid":["PMC8969419"],"pubmed_authors":["Fang Y","Lu J","Chen G","Liu C","Huang L","Dong N","Zeng Y","Sang Z","Zhang R","Wu Y"],"additional_accession":[]},"is_claimable":false,"name":"Emergence of an ST1326 (CG258) Multi-Drug Resistant <i>Klebsiella pneumoniae</i> Co-harboring <i>mcr-8.2</i>, ESBL Genes, and the Resistance-Nodulation-Division Efflux Pump Gene Cluster <i>tmexCD1-toprJ1</i> in China.","description":"CG258 is the dominant carbapenemase-producing <i>Klebsiella pneumoniae</i> clone worldwide and treatment of infections caused by this clone relies largely on the last-line antibiotics, colistin, and tigecycline. However, the emergence and global dissemination of <i>mcr</i> and <i>tmexCD1</i>-<i>toprJ1</i> genes have significantly compromised their clinical applications. CG258 <i>K. pneumoniae</i> carrying both <i>mcr</i> and <i>tmexCD1</i>-<i>toprJ1</i> have not been reported. A colistin-resistant strain T698-1 belonging to ST1326, a member of CG258, was isolated from the intestinal sample of a patient and characterized by the antimicrobial susceptibility testing, conjugation assay, WGS and bioinformatics analysis. It was resistant to colistin, tetracycline, aminoglycoside, fluoroqinolone,","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T12:44:57.216Z","creation":"2025-04-04T12:44:57.216Z"},"accession":"S-EPMC8969419","cross_references":{"pubmed":["35369441"],"doi":["10.3389/fmicb.2022.800993"]}}