{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ursing J"],"funding":["FCT","Svenska Läkaresällskapet","Stockholm County Council","Anthony Cerami and Ann Dunne Foundation for World Health"],"pagination":["1005-1011"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969533"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["77(4)"],"pubmed_abstract":["<h4>Background</h4>Plasmodium falciparum strains that are resistant to standard-dose chloroquine can be treated by higher chloroquine concentrations maintained for a longer time in vivo.<h4>Objectives</h4>To determine the relative importance of chloroquine concentrations versus exposure time for elimination of chloroquine-susceptible and -resistant P. falciparum in vitro.<h4>Methods</h4>Chloroquine-susceptible (3D7) and -resistant (FCR3) strains were exposed in vitro to 1, 2, 4, 8, 16 or 32 times their respective 90% inhibitory chloroquine concentrations for 3, 5, 7 or 14 days and then followed until recrudescence, or not, by 42 days after the end of exposure.<h4>Results</h4>Exposure to chloroquine appeared to eliminate susceptible and resistant parasites, leaving small pyknotic apparently"],"journal":["The Journal of antimicrobial chemotherapy"],"pubmed_title":["Chloroquine-susceptible and -resistant Plasmodium falciparum strains survive high chloroquine concentrations by becoming dormant but are eliminated by prolonged exposure."],"pmcid":["PMC8969533"],"funding_grant_id":["UIDP/50026/2020","UIDB/50026/2020","20160597","20102011"],"pubmed_authors":["Ghanchi NK","Ursing J","Veiga MI","Kofoed PE","Aydin-Schmidt B","Calcada C","Johns R","Rombo L"],"additional_accession":[]},"is_claimable":false,"name":"Chloroquine-susceptible and -resistant Plasmodium falciparum strains survive high chloroquine concentrations by becoming dormant but are eliminated by prolonged exposure.","description":"<h4>Background</h4>Plasmodium falciparum strains that are resistant to standard-dose chloroquine can be treated by higher chloroquine concentrations maintained for a longer time in vivo.<h4>Objectives</h4>To determine the relative importance of chloroquine concentrations versus exposure time for elimination of chloroquine-susceptible and -resistant P. falciparum in vitro.<h4>Methods</h4>Chloroquine-susceptible (3D7) and -resistant (FCR3) strains were exposed in vitro to 1, 2, 4, 8, 16 or 32 times their respective 90% inhibitory chloroquine concentrations for 3, 5, 7 or 14 days and then followed until recrudescence, or not, by 42 days after the end of exposure.<h4>Results</h4>Exposure to chloroquine appeared to eliminate susceptible and resistant parasites, leaving small pyknotic apparently","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T15:18:38.823Z","creation":"2025-04-06T14:50:56.113Z"},"accession":"S-EPMC8969533","cross_references":{"pubmed":["35137072"],"doi":["10.1093/jac/dkac008"]}}