{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murthy VL"],"funding":["NIDDK NIH HHS","NIA NIH HHS","NHLBI NIH HHS","National Heart, Lung, and Blood Institute"],"pagination":["657-674"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969893"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["65(4)"],"pubmed_abstract":["<h4>Aims/hypothesis</h4>The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development.<h4>Methods</h4>We studied 2083 young adults of Black and White ethnicity in the prospective observational cohort Coronary Artery Risk Development in Young Adults (CARDIA) study (mean ± SD age 32.1 ± 3.6 years; 43.9% women; 42.7% Black; mean ± SD BMI 25.6 ± 4.9 kg/m<sup>2</sup>) and 1797 Framingham Heart Study (FHS) participants (mean ± SD age 54.7 ± 9.7 years; 52.1% women; mean ± SD BMI 27.4 ± 4.8 kg/m<sup>2</sup>), examining the association of comprehensive metabolite profiles with endophenotypes of diabetes susceptibility (adipose and muscle tissue phenotypes and systemic inflammation). Statistical"],"journal":["Diabetologia"],"pubmed_title":["Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study."],"pmcid":["PMC8969893"],"funding_grant_id":["R01 HL156975","HHSN268201500001C","R01 DK081572","R01 AG059729","R01 HL136685","R01-HL136685","HHSN268201800005I","HHSN268201800004I","HHSN268201800007I","HHSN268201800006I","K23 HL138260","HHSN268201800003I","75N92019D00031","P30 DK040561","HHSN268201500001I"],"pubmed_authors":["Steffen LM","Vasan RS","Kitchen R","Clish CB","Shah RV","Allen NB","Murthy VL","Lloyd-Jones D","Carnethon M","Freedman JE","Reis JP","Nayor M","Piaggi P"],"additional_accession":[]},"is_claimable":false,"name":"Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study.","description":"<h4>Aims/hypothesis</h4>The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development.<h4>Methods</h4>We studied 2083 young adults of Black and White ethnicity in the prospective observational cohort Coronary Artery Risk Development in Young Adults (CARDIA) study (mean ± SD age 32.1 ± 3.6 years; 43.9% women; 42.7% Black; mean ± SD BMI 25.6 ± 4.9 kg/m<sup>2</sup>) and 1797 Framingham Heart Study (FHS) participants (mean ± SD age 54.7 ± 9.7 years; 52.1% women; mean ± SD BMI 27.4 ± 4.8 kg/m<sup>2</sup>), examining the association of comprehensive metabolite profiles with endophenotypes of diabetes susceptibility (adipose and muscle tissue phenotypes and systemic inflammation). Statistical","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-04T04:59:30.195Z","creation":"2025-04-19T13:30:00.172Z"},"accession":"S-EPMC8969893","cross_references":{"pubmed":["35041022"],"doi":["10.1007/s00125-021-05641-x"]}}