biostudies-literatureMurthy VLNIDDK NIH HHSNIA NIH HHSNHLBI NIH HHSNational Heart, Lung, and Blood Institute657-674https://www.ebi.ac.uk/biostudies/studies/S-EPMC8969893biostudies-literatureUnknown65(4)<h4>Aims/hypothesis</h4>The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development.<h4>Methods</h4>We studied 2083 young adults of Black and White ethnicity in the prospective observational cohort Coronary Artery Risk Development in Young Adults (CARDIA) study (mean ± SD age 32.1 ± 3.6 years; 43.9% women; 42.7% Black; mean ± SD BMI 25.6 ± 4.9 kg/m²) and 1797 Framingham Heart Study (FHS) participants (mean ± SD age 54.7 ± 9.7 years; 52.1% women; mean ± SD BMI 27.4 ± 4.8 kg/m²), examining the association of comprehensive metabolite profiles with endophenotypes of diabetes susceptibility (adipose and muscle tissue phenotypes and systemic inflammation). StatisticalDiabetologiaCirculating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study.PMC8969893R01 HL156975HHSN268201500001CR01 DK081572R01 AG059729R01 HL136685R01-HL136685HHSN268201800005IHHSN268201800004IHHSN268201800007IHHSN268201800006IK23 HL138260HHSN268201800003I75N92019D00031P30 DK040561HHSN268201500001ISteffen LMVasan RSKitchen RClish CBShah RVAllen NBMurthy VLLloyd-Jones DCarnethon MFreedman JEReis JPNayor MPiaggi PfalseCirculating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study.<h4>Aims/hypothesis</h4>The aim of this work was to define metabolic correlates and pathways of diabetes pathogenesis in young adults during a subclinical latent phase of diabetes development.<h4>Methods</h4>We studied 2083 young adults of Black and White ethnicity in the prospective observational cohort Coronary Artery Risk Development in Young Adults (CARDIA) study (mean ± SD age 32.1 ± 3.6 years; 43.9% women; 42.7% Black; mean ± SD BMI 25.6 ± 4.9 kg/m²) and 1797 Framingham Heart Study (FHS) participants (mean ± SD age 54.7 ± 9.7 years; 52.1% women; mean ± SD BMI 27.4 ± 4.8 kg/m²), examining the association of comprehensive metabolite profiles with endophenotypes of diabetes susceptibility (adipose and muscle tissue phenotypes and systemic inflammation). Statistical2022-01-01T00:00:00Z2022 Apr2026-06-04T04:59:30.195Z2025-04-19T13:30:00.172ZS-EPMC89698933504102210.1007/s00125-021-05641-x