biostudies-literatureHartmann WDeutsche Forschungsgemeinschafte0266456https://www.ebi.ac.uk/biostudies/studies/S-EPMC8970517biostudies-literatureUnknown17(3)The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced immunosuppression "spills over" to unrelated antigens and can suppress the immune response to vaccination against other pathogens. Indeed, several human studies have reported a negative correlation between helminth infections and responses to vaccinations. Using mice that are infected with the parasitic nematode Litomosoides sigmodontis as a model for chronic human filarial infections, we reported previously that concurrent helminth infection impaired the vaccination-induced protection against the human pathogenic 2009 pandemic H1N1 influePloS onePre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.PMC89705173754/ 2-1 /2-2Brunn MLGabriel GBreloer MStetter NHartmann WfalsePre-existing helminth infection impairs the efficacy of adjuvanted influenza vaccination in mice.The world health organization estimates that more than a quarter of the human population is infected with parasitic worms that are called helminths. Many helminths suppress the immune system of their hosts to prolong their survival. This helminth-induced immunosuppression "spills over" to unrelated antigens and can suppress the immune response to vaccination against other pathogens. Indeed, several human studies have reported a negative correlation between helminth infections and responses to vaccinations. Using mice that are infected with the parasitic nematode Litomosoides sigmodontis as a model for chronic human filarial infections, we reported previously that concurrent helminth infection impaired the vaccination-induced protection against the human pathogenic 2009 pandemic H1N1 influe2022-01-01T00:00:00Z20222025-05-18T12:06:19.124Z2025-05-18T12:06:19.124ZS-EPMC89705173535828110.1371/journal.pone.0266456