biostudies-literaturePickel LCanada and Sun Life Financial New Investigator AwardBanting and Best Diabetes Centre, University of TorontoChronic Kidney DiseaseCanadian Institutes of Health ResearchCIHR Strategy for Patient Oriented ResearchCIHR652-666https://www.ebi.ac.uk/biostudies/studies/S-EPMC8970828biostudies-literatureUnknown13(2)Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts, leading to the loss of functional nephrons. Recommendations for individuals with ADPKD to maintain a healthy diet and lifestyle are largely similar to those for the general population. However, recent evidence from preclinical models suggests that more tightly specified dietary regimens, including caloric restriction, intermittent fasting, and ketogenic diets, hold promise to slow disease progression, and the results of ongoing human clinical trials are eagerly awaited. These dietary interventions directly influence nutrient signaling and substrate availability in the cystic kidney, while also conferring systemic metabolic benefits. The present review focuses on the importance of local and systemic metabolism in ADPKD and summarizes current evidence for dietary interventions to slow disease progression and improve quality of life.Advances in nutrition (Bethesda, Md.)Dietary Interventions in Autosomal Dominant Polycystic Kidney Disease.PMC8970828PJT-162083CAN-Solve-CKD SCA-145103Sung HKScholey JPickel LIliuta IAPei YfalseDietary Interventions in Autosomal Dominant Polycystic Kidney Disease.Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the progressive growth of renal cysts, leading to the loss of functional nephrons. Recommendations for individuals with ADPKD to maintain a healthy diet and lifestyle are largely similar to those for the general population. However, recent evidence from preclinical models suggests that more tightly specified dietary regimens, including caloric restriction, intermittent fasting, and ketogenic diets, hold promise to slow disease progression, and the results of ongoing human clinical trials are eagerly awaited. These dietary interventions directly influence nutrient signaling and substrate availability in the cystic kidney, while also conferring systemic metabolic benefits. The present review focuses on the importance of local and systemic metabolism in ADPKD and summarizes current evidence for dietary interventions to slow disease progression and improve quality of life.2022-01-01T00:00:00Z2022 Mar2025-05-29T16:11:49.118Z2025-04-04T09:31:59.185ZS-EPMC89708283475583110.1093/advances/nmab131