{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Shen X"],"funding":["National Natural Science Foundation of China"],"pagination":["2461716"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8970858"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["<h4>Background</h4>Osteoporosis is a systemic bone disease characterized by reduction of bone content. Bisphosphonates are first-line treatments for osteoporosis, but they have variable effectiveness. Genetic factors may explain these differences. The NF-<i>κ</i>B signaling pathway plays a key role in the regulation of bone metabolism. We aimed to determine whether genetic variations in the NF-<i>κ</i>B signaling pathway affect the effectiveness of alendronate in postmenopausal Chinese women with low bone mass.<h4>Methods</h4>We recruited 455 postmenopausal Han Chinese women with primary osteoporosis or osteopenia aged 48-90 yrs who had experienced no spontaneous menses for at least 1 yr. All participants had dual X-ray absorptiometry (DEXA) bone mineral density (BMD) measurement at baseli"],"journal":["Evidence-based complementary and alternative medicine : eCAM"],"pubmed_title":["Association between NF-<i>κ</i>B Signal Pathway-Related Gene Polymorphisms and Response to Alendronate Treatment in Postmenopausal Chinese Women with Low Bone Mineral Density."],"pmcid":["PMC8970858"],"funding_grant_id":["2016ZCL J020","81770872"],"pubmed_authors":["Hu Y","Liu L","Feng X","Wang C","Fu W","Hua F","Tan S","Wang W","Yuan H","Shen X","Li M"],"additional_accession":[]},"is_claimable":false,"name":"Association between NF-<i>κ</i>B Signal Pathway-Related Gene Polymorphisms and Response to Alendronate Treatment in Postmenopausal Chinese Women with Low Bone Mineral Density.","description":"<h4>Background</h4>Osteoporosis is a systemic bone disease characterized by reduction of bone content. Bisphosphonates are first-line treatments for osteoporosis, but they have variable effectiveness. Genetic factors may explain these differences. The NF-<i>κ</i>B signaling pathway plays a key role in the regulation of bone metabolism. We aimed to determine whether genetic variations in the NF-<i>κ</i>B signaling pathway affect the effectiveness of alendronate in postmenopausal Chinese women with low bone mass.<h4>Methods</h4>We recruited 455 postmenopausal Han Chinese women with primary osteoporosis or osteopenia aged 48-90 yrs who had experienced no spontaneous menses for at least 1 yr. All participants had dual X-ray absorptiometry (DEXA) bone mineral density (BMD) measurement at baseli","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T13:09:53.704Z","creation":"2025-04-06T14:08:04.347Z"},"accession":"S-EPMC8970858","cross_references":{"pubmed":["35368772"],"doi":["10.1155/2022/2461716"]}}