biostudies-literatureStoffel NUNational Science Foundation1166-1179https://www.ebi.ac.uk/biostudies/studies/S-EPMC8970997biostudies-literatureUnknown115(4)<h4>Background</h4>Inflammation during pregnancy may aggravate iron deficiency (ID) by increasing serum hepcidin and reducing iron absorption. This could restrict iron transfer to the fetus, increasing risk of infant ID and its adverse effects.<h4>Objectives</h4>We aimed to assess whether iron bioavailability and/or iron transfer to the fetus is impaired in overweight/obese (OW) pregnant women with adiposity-related inflammation, compared with normal-weight (NW) pregnant women.<h4>Methods</h4>In this prospective study, we followed NW (n = 43) and OW (n = 40) pregnant women who were receiving iron supplements from the 14th week of gestation to term and followed their infants to age 6 mo. We administered 57Fe and 58Fe in test meals mid-second and mid-third trimester, and measured tracer kineThe American journal of clinical nutritionMaternal iron kinetics and maternal-fetal iron transfer in normal-weight and overweight pregnancy.PMC8970997320030_156449Zeder CZimmermann MBCepeda-Lopez ACTuntipopipat SMoungmaithong SDensupsoontorn NQuack Loetscher KLlanas-Cornejo DGowachirapant SHerter-Aeberli IStoffel NUCervantes-Gracia KfalseMaternal iron kinetics and maternal-fetal iron transfer in normal-weight and overweight pregnancy.<h4>Background</h4>Inflammation during pregnancy may aggravate iron deficiency (ID) by increasing serum hepcidin and reducing iron absorption. This could restrict iron transfer to the fetus, increasing risk of infant ID and its adverse effects.<h4>Objectives</h4>We aimed to assess whether iron bioavailability and/or iron transfer to the fetus is impaired in overweight/obese (OW) pregnant women with adiposity-related inflammation, compared with normal-weight (NW) pregnant women.<h4>Methods</h4>In this prospective study, we followed NW (n = 43) and OW (n = 40) pregnant women who were receiving iron supplements from the 14th week of gestation to term and followed their infants to age 6 mo. We administered 57Fe and 58Fe in test meals mid-second and mid-third trimester, and measured tracer kine2022-01-01T00:00:00Z2022 Apr2026-05-31T07:13:58.045Z2025-02-18T23:37:00.228ZS-EPMC89709973491011810.1093/ajcn/nqab406