{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["14(3)"],"submitter":["Alsayed BA"],"pubmed_abstract":["Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, namely, angiotensin-converting enzyme 2 (ACE2-rs4646994 I/D) gene, glutathione S-transferase (GST) M1 and T1 gene, and miR-423 rs6505162 C>A gene polymorphism. Results showed that the ACE-DD genotype of ACE2, (GSTM1+/+) (GSTT1-/-) genotype of GST gene, and CA genotype (heterozygosity) of miR-423 rs6505162 genes, which were found in the patient, could be independent risk factors of severe COVID-19, even without comorbidities."],"journal":["Cureus"],"pagination":["e23636"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8971094"],"repository":["biostudies-literature"],"pubmed_title":["Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review."],"pmcid":["PMC8971094"],"pubmed_authors":["Mir R","Alsayed BA"],"additional_accession":[]},"is_claimable":false,"name":"Severe COVID-19 Pneumonia and Genetic Susceptibility: A Case Report and Literature Review.","description":"Genetic susceptibility to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) morbidity and mortality continues to evolve. This report presents a case of an apparently healthy male adult who developed severe coronavirus disease 2019 (COVID-19) and a study on relevant genetic mutations, namely, angiotensin-converting enzyme 2 (ACE2-rs4646994 I/D) gene, glutathione S-transferase (GST) M1 and T1 gene, and miR-423 rs6505162 C>A gene polymorphism. Results showed that the ACE-DD genotype of ACE2, (GSTM1+/+) (GSTT1-/-) genotype of GST gene, and CA genotype (heterozygosity) of miR-423 rs6505162 genes, which were found in the patient, could be independent risk factors of severe COVID-19, even without comorbidities.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T12:45:20.97Z","creation":"2025-04-04T12:45:20.97Z"},"accession":"S-EPMC8971094","cross_references":{"pubmed":["35371838"],"doi":["10.7759/cureus.23636"]}}