{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["6(1)"],"submitter":["Zhang Y"],"pubmed_abstract":["This retrospective study investigated the association between the pattern of disease progression and molecular mechanism of acquired resistance in a large cohort of 49 patients with ROS1-rearranged advanced non-small-cell lung cancer treated with first-line crizotinib. We found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly for patients who developed extracranial-only disease progression. Our findings highlight the importance of rebiopsy and gene testing for subsequent-line therapeutic management."],"journal":["NPJ precision oncology"],"pagination":["20"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8971474"],"repository":["biostudies-literature"],"pubmed_title":["Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements."],"pmcid":["PMC8971474"],"pubmed_authors":["Yang H","Lizaso A","Liu J","Zeng L","Yang N","Xu Q","Xu C","Li Y","Huang Z","Zhang Y","Zhang X","Wang W","Song Z","Ou SI"],"additional_accession":[]},"is_claimable":false,"name":"Disease progression patterns and molecular resistance mechanisms to crizotinib of lung adenocarcinoma harboring ROS1 rearrangements.","description":"This retrospective study investigated the association between the pattern of disease progression and molecular mechanism of acquired resistance in a large cohort of 49 patients with ROS1-rearranged advanced non-small-cell lung cancer treated with first-line crizotinib. We found that treatment-emergent ROS1 point mutations were the major molecular mechanism of crizotinib resistance, particularly for patients who developed extracranial-only disease progression. Our findings highlight the importance of rebiopsy and gene testing for subsequent-line therapeutic management.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T17:38:05.283Z","creation":"2025-04-19T17:38:05.283Z"},"accession":"S-EPMC8971474","cross_references":{"pubmed":["35361870"],"doi":["10.1038/s41698-022-00264-w"]}}