biostudies-literatureUnknown13Du R<h4>Objective</h4>The objective of this study was to reveal the potential crosstalk between immune infiltration and N⁶- methyladenosine (m⁶A) modification in the placentas of patients with gestational diabetes mellitus (GDM), and to construct a model for the diagnosis of GDM.<h4>Methods</h4>We analyzed imbalanced immune infiltration and differentially expressed m⁶A-related genes (DMRGs) in the placentas of patients with GDM, based on the GSE70493 dataset. An immune-related DMRG signature, with significant classifying power and diagnostic value, was identified using a least absolute shrinkage and selection operator (LASSO) regression. Based on the selected DMRGs, we developed and validated a nomogram model using GSE70493 and GSE92772 as the training and valiFrontiers in endocrinology853857https://www.ebi.ac.uk/biostudies/studies/S-EPMC8971567biostudies-literatureN6-Methyladenosine-Related Gene Signature Associated With Monocyte Infiltration Is Clinically Significant in Gestational Diabetes Mellitus.PMC8971567Du RWang YLi LfalseN6-Methyladenosine-Related Gene Signature Associated With Monocyte Infiltration Is Clinically Significant in Gestational Diabetes Mellitus.<h4>Objective</h4>The objective of this study was to reveal the potential crosstalk between immune infiltration and N⁶- methyladenosine (m⁶A) modification in the placentas of patients with gestational diabetes mellitus (GDM), and to construct a model for the diagnosis of GDM.<h4>Methods</h4>We analyzed imbalanced immune infiltration and differentially expressed m⁶A-related genes (DMRGs) in the placentas of patients with GDM, based on the GSE70493 dataset. An immune-related DMRG signature, with significant classifying power and diagnostic value, was identified using a least absolute shrinkage and selection operator (LASSO) regression. Based on the selected DMRGs, we developed and validated a nomogram model using GSE70493 and GSE92772 as the training and vali2022-01-01T00:00:00Z20222025-04-19T12:55:59.605Z2025-04-19T12:55:59.605ZS-EPMC89715673537094010.3389/fendo.2022.853857