{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18"],"submitter":["Yoon HJ"],"pubmed_abstract":["All-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable hydrogels. Furthermore, molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free therapy. This study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable component. These properties enabled spraying of the hydrogel onto the intestinal walls during endoscopy. Next, peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adh"],"journal":["Bioactive materials"],"pagination":["433-445"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8971598"],"repository":["biostudies-literature"],"pubmed_title":["Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy."],"pmcid":["PMC8971598"],"pubmed_authors":["Lee S","Chung S","Wang EK","Kim TY","Kim HJ","Shin YC","Kim HS","Chung YS","Yu SE","Park S","Shin YM","Yoon HJ","Noh J","Sung HJ","Park JS","Ku CR","Kim CS","Koh H"],"additional_accession":[]},"is_claimable":false,"name":"Sprayable nanomicelle hydrogels and inflammatory bowel disease patient cell chips for development of intestinal lesion-specific therapy.","description":"All-in-one treatments represent a paradigm shift in future medicine. For example, inflammatory bowel disease (IBD) is mainly diagnosed by endoscopy, which could be applied for not only on-site monitoring but also the intestinal lesion-targeted spray of injectable hydrogels. Furthermore, molecular conjugation to the hydrogels would program both lesion-specific adhesion and drug-free therapy. This study validated this concept of all-in-one treatment by first utilizing a well-known injectable hydrogel that underwent efficient solution-to-gel transition and nanomicelle formation as a translatable component. These properties enabled spraying of the hydrogel onto the intestinal walls during endoscopy. Next, peptide conjugation to the hydrogel guided endoscopic monitoring of IBD progress upon adh","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Dec","modification":"2025-05-31T23:49:15.556Z","creation":"2025-05-31T23:49:15.556Z"},"accession":"S-EPMC8971598","cross_references":{"pubmed":["35415304"],"doi":["10.1016/j.bioactmat.2022.03.031"]}}