biostudies-literatureUnknown13Sanz MBExtraintestinal pathogenic <i>Escherichia coli</i> (ExPEC) causes infections outside the intestine. Particular ExPEC clones, such as clonal complex (CC)/sequence type (ST)131, have been known to sequentially accumulate antimicrobial resistance that starts with chromosomal mutations against fluoroquinolones, followed with the acquisition of <i>bla</i> _CTX-M-15 and, more recently, carbapenemases. Here we aimed to investigate the distribution of global epidemic clones of carbapenemase-producing ExPEC from Argentina in representative clinical isolates recovered between July 2008 and March 2017. Carbapenemase-producing ExPEC (<i>n</i> = 160) were referred to the Argentinean reference laboratory. Of these, 71 were selected for genome sequencing. Phenotypic and microbiological studies Frontiers in microbiology830209https://www.ebi.ac.uk/biostudies/studies/S-EPMC8971848biostudies-literatureCarbapenemase-Producing Extraintestinal Pathogenic <i>Escherichia coli</i> From Argentina: Clonal Diversity and Predominance of Hyperepidemic Clones CC10 and CC131.PMC8971848Rocallo MGral HTula CPiersigulli ASujemecki ARomeo AMCerda NGonzalez LPidone JCGerardo MSantojanni HAlfonodo CSauer HFlabiani MAleman HManganello SVisus MAVacaflor LGiudice NErrecalde LBottinelli LCampos JLucero Cde Paulis ABardi LNunez MRArchuby DFaccone DRapoport MBartoli MZPoklepovich TCorso ARosato AEVeliz OTogneri ASanz MBCarbapenemases-ExPEC GroupAndres PReynaldi MRodriguez ANaval Hde Agudos HGBiondi EVan der Ploeg CDi Bella AVilaro MGomez SAPasteran FOrtiz SCarol Rey MLittvik AZarate SHeller HRoge ATuduri EBaudaz BDe Belder Dde Mendieta JMSaavedra MOBadi MMarinansky ALBongiovanni MEfalseCarbapenemase-Producing Extraintestinal Pathogenic <i>Escherichia coli</i> From Argentina: Clonal Diversity and Predominance of Hyperepidemic Clones CC10 and CC131.Extraintestinal pathogenic <i>Escherichia coli</i> (ExPEC) causes infections outside the intestine. Particular ExPEC clones, such as clonal complex (CC)/sequence type (ST)131, have been known to sequentially accumulate antimicrobial resistance that starts with chromosomal mutations against fluoroquinolones, followed with the acquisition of <i>bla</i> _CTX-M-15 and, more recently, carbapenemases. Here we aimed to investigate the distribution of global epidemic clones of carbapenemase-producing ExPEC from Argentina in representative clinical isolates recovered between July 2008 and March 2017. Carbapenemase-producing ExPEC (<i>n</i> = 160) were referred to the Argentinean reference laboratory. Of these, 71 were selected for genome sequencing. Phenotypic and microbiological studies 2022-01-01T00:00:00Z20222026-04-08T18:16:25.775Z2025-02-19T04:22:50.454ZS-EPMC89718483536946910.3389/fmicb.2022.830209