{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12(17)"],"submitter":["Sanz Del Olmo N"],"pubmed_abstract":["Reactive oxygen species (ROS) play a critical role in different human pathophysiological processes. ROS, together with nitrogen reactive species, generated as by-products of cellular metabolism or external factors, affects intracellular redox homeostasis. Redox-active groups found in proteins and other compounds such as polyphenols are involved in maintaining intracellular redox homeostasis. In this work, a new family of heterofunctional first-generation carbosilane dendrons functionalised with different polyphenols at the focal point and dimethylammonium groups at the periphery has been obtained through two synthetic strategies: reductive amination and straightforward amidation reaction. Their antioxidant activity has been evaluated through two spectrophotometric methods: ferric reducing antioxidant power (FRAP) assay and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay to establish a correlation between the number of hydroxyl groups and the antioxidant activity."],"journal":["RSC advances"],"pagination":["10280-10288"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8972098"],"repository":["biostudies-literature"],"pubmed_title":["Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms."],"pmcid":["PMC8972098"],"pubmed_authors":["Garcia JC","Gomez R","de la Mata FJ","Ortega P","Sanz Del Olmo N"],"additional_accession":[]},"is_claimable":false,"name":"Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms.","description":"Reactive oxygen species (ROS) play a critical role in different human pathophysiological processes. ROS, together with nitrogen reactive species, generated as by-products of cellular metabolism or external factors, affects intracellular redox homeostasis. Redox-active groups found in proteins and other compounds such as polyphenols are involved in maintaining intracellular redox homeostasis. In this work, a new family of heterofunctional first-generation carbosilane dendrons functionalised with different polyphenols at the focal point and dimethylammonium groups at the periphery has been obtained through two synthetic strategies: reductive amination and straightforward amidation reaction. Their antioxidant activity has been evaluated through two spectrophotometric methods: ferric reducing antioxidant power (FRAP) assay and 2,2'-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay to establish a correlation between the number of hydroxyl groups and the antioxidant activity.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T12:58:35.589Z","creation":"2025-04-19T12:58:35.589Z"},"accession":"S-EPMC8972098","cross_references":{"pubmed":["35424993"],"doi":["10.1039/d1ra08224h"]}}