{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Freudenberg-Hua Y"],"funding":["National Institute on Aging"],"pubmed_abstract":["<h4>Background</h4>COVID-19 has been associated with an increased risk of incident dementia (post-COVID dementia). Establishing additional risk markers may help identify at-risk individuals and guide clinical decision-making.<h4>Methods</h4>We investigated pre-COVID psychotropic medication use (exposure) and 1-year incidence of dementia (outcome) in 1,755 patients (≥65 years) hospitalized with COVID-19. Logistic regression models were used to examine the association, adjusting for demographic and clinical variables. For further confirmation, we applied the Least Absolute Shrinkage and Selection Operator (LASSO) regression and a machine learning (Random Forest) algorithm.<h4>Results</h4>One-year incidence rate of post-COVID dementia was 12.7% (<i>N</i> = 223). Pre-COVID psychotropic medicat"],"journal":["Frontiers in medicine"],"pagination":["841326"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8972194"],"repository":["biostudies-literature"],"pubmed_title":["Psychotropic Medication Use Is Associated With Greater 1-Year Incidence of Dementia After COVID-19 Hospitalization."],"pmcid":["PMC8972194"],"pubmed_authors":["Marziliano A","Kane JM","Greenwald B","Carney M","Qiu M","Li W","Liu Y","Koppel J","Freudenberg-Hua Y","Burns E","Sinvani L","Makhnevich A","Diefenbach M"],"additional_accession":[]},"is_claimable":false,"name":"Psychotropic Medication Use Is Associated With Greater 1-Year Incidence of Dementia After COVID-19 Hospitalization.","description":"<h4>Background</h4>COVID-19 has been associated with an increased risk of incident dementia (post-COVID dementia). Establishing additional risk markers may help identify at-risk individuals and guide clinical decision-making.<h4>Methods</h4>We investigated pre-COVID psychotropic medication use (exposure) and 1-year incidence of dementia (outcome) in 1,755 patients (≥65 years) hospitalized with COVID-19. Logistic regression models were used to examine the association, adjusting for demographic and clinical variables. For further confirmation, we applied the Least Absolute Shrinkage and Selection Operator (LASSO) regression and a machine learning (Random Forest) algorithm.<h4>Results</h4>One-year incidence rate of post-COVID dementia was 12.7% (<i>N</i> = 223). Pre-COVID psychotropic medicat","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-06-01T01:33:38.8Z","creation":"2024-11-14T02:05:50.424Z"},"accession":"S-EPMC8972194","cross_references":{"pubmed":["35372430"],"doi":["10.3389/fmed.2022.841326"]}}