biostudies-literatureUnknown9Freudenberg-Hua YNational Institute on Aging<h4>Background</h4>COVID-19 has been associated with an increased risk of incident dementia (post-COVID dementia). Establishing additional risk markers may help identify at-risk individuals and guide clinical decision-making.<h4>Methods</h4>We investigated pre-COVID psychotropic medication use (exposure) and 1-year incidence of dementia (outcome) in 1,755 patients (≥65 years) hospitalized with COVID-19. Logistic regression models were used to examine the association, adjusting for demographic and clinical variables. For further confirmation, we applied the Least Absolute Shrinkage and Selection Operator (LASSO) regression and a machine learning (Random Forest) algorithm.<h4>Results</h4>One-year incidence rate of post-COVID dementia was 12.7% (<i>N</i> = 223). Pre-COVID psychotropic medicatFrontiers in medicine841326https://www.ebi.ac.uk/biostudies/studies/S-EPMC8972194biostudies-literaturePsychotropic Medication Use Is Associated With Greater 1-Year Incidence of Dementia After COVID-19 Hospitalization.PMC8972194Marziliano AKane JMGreenwald BCarney MQiu MLi WLiu YKoppel JFreudenberg-Hua YBurns ESinvani LMakhnevich ADiefenbach MfalsePsychotropic Medication Use Is Associated With Greater 1-Year Incidence of Dementia After COVID-19 Hospitalization.<h4>Background</h4>COVID-19 has been associated with an increased risk of incident dementia (post-COVID dementia). Establishing additional risk markers may help identify at-risk individuals and guide clinical decision-making.<h4>Methods</h4>We investigated pre-COVID psychotropic medication use (exposure) and 1-year incidence of dementia (outcome) in 1,755 patients (≥65 years) hospitalized with COVID-19. Logistic regression models were used to examine the association, adjusting for demographic and clinical variables. For further confirmation, we applied the Least Absolute Shrinkage and Selection Operator (LASSO) regression and a machine learning (Random Forest) algorithm.<h4>Results</h4>One-year incidence rate of post-COVID dementia was 12.7% (<i>N</i> = 223). Pre-COVID psychotropic medicat2022-01-01T00:00:00Z20222025-06-01T01:33:38.8Z2024-11-14T02:05:50.424ZS-EPMC89721943537243010.3389/fmed.2022.841326