{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Mossad SI"],"funding":["CIHR"],"pagination":["377-386"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8972272"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["17(4)"],"pubmed_abstract":["Very preterm (VPT: ≤32 weeks of gestational age) birth poses an increased risk for social and cognitive morbidities that persist throughout life. Resting-state functional network connectivity studies provide information about the intrinsic capacity for cognitive processing. We studied the following four social-cognitive resting-state networks: the default mode, salience, frontal-parietal and language networks. We examined functional connectivity using magnetoencephalography with individual head localization using each participant's MRI at 6 (n = 40) and 8 (n = 40) years of age compared to age- and sex-matched full-term (FT) born children (n = 38 at 6 years and n = 43 at 8 years). VPT children showed increased connectivity compared to FT children in the gamma band (30-80 Hz) at 6 years within the default mode network (DMN), and between the DMN and the salience, frontal-parietal and language networks, pointing to more diffuse, less segregated processing across networks at this age. At 8 years, VPT children had more social and academic difficulties. Increased DMN connectivity at 6 years was associated with social and working memory difficulties at 8 years. Therefore, we suggest that increased DMN connectivity contributes to the observed emerging social and cognitive morbidities in school age."],"journal":["Social cognitive and affective neuroscience"],"pubmed_title":["Very preterm brain at rest: longitudinal social-cognitive network connectivity during childhood."],"pmcid":["PMC8972272"],"funding_grant_id":["MOP-137115"],"pubmed_authors":["Dunkley BT","Mossad SI","Young JM","Wong SM","Hunt BAE","Pang EW","Taylor MJ"],"additional_accession":[]},"is_claimable":false,"name":"Very preterm brain at rest: longitudinal social-cognitive network connectivity during childhood.","description":"Very preterm (VPT: ≤32 weeks of gestational age) birth poses an increased risk for social and cognitive morbidities that persist throughout life. Resting-state functional network connectivity studies provide information about the intrinsic capacity for cognitive processing. We studied the following four social-cognitive resting-state networks: the default mode, salience, frontal-parietal and language networks. We examined functional connectivity using magnetoencephalography with individual head localization using each participant's MRI at 6 (n = 40) and 8 (n = 40) years of age compared to age- and sex-matched full-term (FT) born children (n = 38 at 6 years and n = 43 at 8 years). VPT children showed increased connectivity compared to FT children in the gamma band (30-80 Hz) at 6 years within the default mode network (DMN), and between the DMN and the salience, frontal-parietal and language networks, pointing to more diffuse, less segregated processing across networks at this age. At 8 years, VPT children had more social and academic difficulties. Increased DMN connectivity at 6 years was associated with social and working memory difficulties at 8 years. Therefore, we suggest that increased DMN connectivity contributes to the observed emerging social and cognitive morbidities in school age.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-04T21:33:34.158Z","creation":"2025-04-04T21:33:34.158Z"},"accession":"S-EPMC8972272","cross_references":{"pubmed":["34654932"],"doi":["10.1093/scan/nsab110"]}}