{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"submitter":["Ding X"],"pubmed_abstract":["Leaf senescence is a highly-programmed developmental process during the plant life cycle. ABA plays an important role in leaf senescence. However, the mechanism underlying ABA-mediated leaf senescence, particularly the upstream epigenetic regulatory network, remains largely unclear. Here, we identified that SlJMJ4, a Jumonji C (jmjC) domain-containing protein in tomato, specifically demethylates di- and tri-methylations of lysine 27 of histone H3 (H3K27) in vitro and in vivo. Overexpression of SlJMJ4 results in premature senescence phenotype and promotes dark- and ABA-induced leaf senescence in tomato. Under dark condition, SlJMJ4-promoted leaf senescence is associated with upregulated expression of transcription factors (SlORE1 and SlNAP2) and senescence-associated genes (SlSAG113, SlSAG1"],"journal":["Horticulture research"],"pagination":["uhab077"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8973004"],"repository":["biostudies-literature"],"pubmed_title":["Histone H3K27 demethylase SlJMJ4 promotes dark- and ABA- induced leaf senescence in tomato."],"pmcid":["PMC8973004"],"pubmed_authors":["Gu D","Jiang Y","Ding X","Zhang D","Li Z","Liang H","Zhu H","Duan X"],"additional_accession":[]},"is_claimable":false,"name":"Histone H3K27 demethylase SlJMJ4 promotes dark- and ABA- induced leaf senescence in tomato.","description":"Leaf senescence is a highly-programmed developmental process during the plant life cycle. ABA plays an important role in leaf senescence. However, the mechanism underlying ABA-mediated leaf senescence, particularly the upstream epigenetic regulatory network, remains largely unclear. Here, we identified that SlJMJ4, a Jumonji C (jmjC) domain-containing protein in tomato, specifically demethylates di- and tri-methylations of lysine 27 of histone H3 (H3K27) in vitro and in vivo. Overexpression of SlJMJ4 results in premature senescence phenotype and promotes dark- and ABA-induced leaf senescence in tomato. Under dark condition, SlJMJ4-promoted leaf senescence is associated with upregulated expression of transcription factors (SlORE1 and SlNAP2) and senescence-associated genes (SlSAG113, SlSAG1","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2026-04-07T13:20:26.001Z","creation":"2025-04-05T22:18:27.126Z"},"accession":"S-EPMC8973004","cross_references":{"pubmed":["35043207"],"doi":["10.1093/hr/uhab077"]}}