{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Che Y"],"funding":["Natural Science Foundation of Jiangxi Province"],"pagination":["6839-6855"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8973660"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(3)"],"pubmed_abstract":["microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p's influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis. <i>In vivo</i>, miR-381-3p expression was abate"],"journal":["Bioengineered"],"pubmed_title":["Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis."],"pmcid":["PMC8973660"],"funding_grant_id":["20202BAB206061"],"pubmed_authors":["Li X","He J","Zhang Y","Che Y","Wu D","Yuan G"],"additional_accession":[]},"is_claimable":false,"name":"Overexpression of microRNA-381-3p ameliorates hypoxia/ischemia-induced neuronal damage and microglial inflammation via regulating the C-C chemokine receptor type 2 /nuclear transcription factor-kappa B axis.","description":"microRNAs, as small endogenous RNAs, influence umpteen sophisticated cellular biological functions regarding neurodegenerative and cerebrovascular diseases. Here, we interrogated miR-381-3p's influence on BV2 activation and neurotoxicity in ischemic and hypoxic environment. Oxygen-glucose deprivation (OGD) was adopted to induce microglial activation and HT-22 neuron damage. Quantitative polymerase chain reaction (qRT-PCR) was taken to check miR-381-3p expression in OGD-elicited BV2 cells and HT-22 neurons. It transpired that miR-381-3p expression was lowered in BV2 cells and HT-22 cells elicited by OGD. miR-381-3p up-regulation remarkably hampered inflammatory mediator expression in BV2 cells induced by OGD and weakened HT22 neuron apoptosis. <i>In vivo</i>, miR-381-3p expression was abate","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-03-18T14:18:35.852Z","creation":"2025-08-23T03:08:57.528Z"},"accession":"S-EPMC8973660","cross_references":{"pubmed":["35246016"],"doi":["10.1080/21655979.2022.2038448"]}}