{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(4)"],"submitter":["Masa JF"],"pubmed_abstract":["Study objectives
Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.Methods
In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a P value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.Results
Of 246 patients with OHS, 122 (50%) had echoca"],"journal":["Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine"],"pagination":["983-992"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974388"],"repository":["biostudies-literature"],"pubmed_title":["Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome."],"pmcid":["PMC8974388"],"pubmed_authors":["Marti S","Javaheri S","Caballero-Eraso C","Benitez ID","Mogollon MV","Barbe F","Mokhlesi B","Romero A","Gonzalez M","Lopez-Martin S","Barca J","de Terreros FJG","Ordax-Carbajo E","Troncoso MF","Sanchez-Quiroga MA","Egea C","Marin JM","Spanish Sleep Network","Masa JF","Gallego R","Chiner E","Corral J","Diaz-Cambriles T"],"additional_accession":[]},"is_claimable":false,"name":"Risk factors associated with pulmonary hypertension in obesity hypoventilation syndrome.","description":"Study objectives
Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.Methods
In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a P value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.Results
Of 246 patients with OHS, 122 (50%) had echoca","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-06-13T06:18:54.713Z","creation":"2025-04-06T11:14:19.55Z"},"accession":"S-EPMC8974388","cross_references":{"pubmed":["34755598"],"doi":["10.5664/jcsm.9760"]}}