biostudies-literatureUnknown18(4)Masa JF<h4>Study objectives</h4>Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.<h4>Methods</h4>In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a <i>P</i> value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.<h4>Results</h4>Of 246 patients with OHS, 122 (50%) had echocaJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine983-992https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974388biostudies-literatureRisk factors associated with pulmonary hypertension in obesity hypoventilation syndrome.PMC8974388Marti SJavaheri SCaballero-Eraso CBenitez IDMogollon MVBarbe FMokhlesi BRomero AGonzalez MLopez-Martin SBarca Jde Terreros FJGOrdax-Carbajo ETroncoso MFSanchez-Quiroga MAEgea CMarin JMSpanish Sleep NetworkMasa JFGallego RChiner ECorral JDiaz-Cambriles TfalseRisk factors associated with pulmonary hypertension in obesity hypoventilation syndrome.<h4>Study objectives</h4>Pulmonary hypertension (PH) is prevalent in obesity hypoventilation syndrome (OHS). However, there is a paucity of data assessing pathogenic factors associated with PH. Our objective is to assess risk factors that may be involved in the pathogenesis of PH in untreated OHS.<h4>Methods</h4>In a post hoc analysis of the Pickwick trial, we performed a bivariate analysis of baseline characteristics between patients with and without PH. Variables with a <i>P</i> value ≤ .10 were defined as potential risk factors and were grouped by theoretical pathogenic mechanisms in several adjusted models. Similar analysis was carried out for the 2 OHS phenotypes, with and without severe concomitant obstructive sleep apnea.<h4>Results</h4>Of 246 patients with OHS, 122 (50%) had echoca2022-01-01T00:00:00Z2022 Apr2026-06-13T06:18:54.713Z2025-04-06T11:14:19.55ZS-EPMC89743883475559810.5664/jcsm.9760