{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ge J"],"funding":["Natural Science Foundation of Hunan Province","National Natural Science Foundation of China"],"pagination":["5074-5088"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974435"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["81(19)"],"pubmed_abstract":["Epstein-Barr virus (EBV) infection is an established cause of nasopharyngeal carcinoma (NPC) and is involved in a variety of malignant phenotypes, including tumor immune escape. EBV can encode a variety of circular RNAs (circRNA), however, little is known regarding the biological functions of these circRNAs in NPC. In this study, EBV-encoded <i>circBART2.2</i> was found to be highly expressed in NPC where it upregulated PD-L1 expression and inhibited T-cell function <i>in vitro</i> and <i>in vivo</i>. <i>circBART2.2</i> promoted transcription of PD-L1 by binding the helicase domain of RIG-I and activating transcription factors IRF3 and NF-κB, resulting in tumor immune escape. These results elucidate the biological function of <i>circBART2.2</i>, explain a novel mechanism of immune escape caused by EBV infection, and provide a new immunotherapy target for treating NPC. SIGNIFICANCE: This work demonstrates that <i>circBART2.2</i> binding to RIG-I is essential for the regulation of PD-L1 and subsequent immune escape in nasopharyngeal carcinoma."],"journal":["Cancer research"],"pubmed_title":["Epstein-Barr Virus-Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1."],"pmcid":["PMC8974435"],"funding_grant_id":["2019JJ50872","U20A20367","81772928","81972776","81803025"],"pubmed_authors":["Zhou M","Li G","Shi L","Zeng Z","Ge J","Wang F","Gong Z","Zhang S","Wang J","Xiong W","Xiang B","Li X","Li Y","He Y","Jiang X","Zhu K","Guo C","Wang Y","Xiong F","Mo Y"],"additional_accession":[]},"is_claimable":false,"name":"Epstein-Barr Virus-Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1.","description":"Epstein-Barr virus (EBV) infection is an established cause of nasopharyngeal carcinoma (NPC) and is involved in a variety of malignant phenotypes, including tumor immune escape. EBV can encode a variety of circular RNAs (circRNA), however, little is known regarding the biological functions of these circRNAs in NPC. In this study, EBV-encoded <i>circBART2.2</i> was found to be highly expressed in NPC where it upregulated PD-L1 expression and inhibited T-cell function <i>in vitro</i> and <i>in vivo</i>. <i>circBART2.2</i> promoted transcription of PD-L1 by binding the helicase domain of RIG-I and activating transcription factors IRF3 and NF-κB, resulting in tumor immune escape. These results elucidate the biological function of <i>circBART2.2</i>, explain a novel mechanism of immune escape caused by EBV infection, and provide a new immunotherapy target for treating NPC. SIGNIFICANCE: This work demonstrates that <i>circBART2.2</i> binding to RIG-I is essential for the regulation of PD-L1 and subsequent immune escape in nasopharyngeal carcinoma.","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Oct","modification":"2026-05-09T22:16:01.291Z","creation":"2025-04-04T20:22:25.245Z"},"accession":"S-EPMC8974435","cross_references":{"pubmed":["34321242"],"doi":["10.1158/0008-5472.CAN-20-4321"]}}