{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["2"],"submitter":["Datema MR"],"funding":["European Commission"],"pubmed_abstract":["<b>Background:</b> It is not well-understood why symptom severity varies between patients with peanut allergy (PA). <b>Objective:</b> To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. <b>Methods:</b> Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. <b>Results:</b> Female sex, age at onset of PA, symptoms elicited by skin contact with peanu"],"journal":["Frontiers in allergy"],"pagination":["670789"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974676"],"repository":["biostudies-literature"],"pubmed_title":["Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles."],"pmcid":["PMC8974676"],"pubmed_authors":["Kowalski ML","Vieths S","Vassilopoulou E","Sinaniotis A","Fritsche P","Welsing PMJ","Mills ENC","Gislason D","Popov TA","de Blay F","Zwinderman AH","Hoffmann-Sommergruber K","Papadopoulos NG","Clausen M","Fernandez-Perez C","Kralimarkova TZ","Belohlavkova S","Barreales L","Versteeg SA","Asero R","Purohit A","Ballmer-Weber B","Fernandez-Rivas M","Reig I","Jongejan L","Datema MR","Knulst AC","Jedrzejczak-Czechowicz M","Lidholm J","Del Prado N","Le TM","Lyons SA","Dubakiene R","Seneviratne SL","van Ree R"],"additional_accession":[]},"is_claimable":false,"name":"Estimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.","description":"<b>Background:</b> It is not well-understood why symptom severity varies between patients with peanut allergy (PA). <b>Objective:</b> To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. <b>Methods:</b> Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. <b>Results:</b> Female sex, age at onset of PA, symptoms elicited by skin contact with peanu","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2025-04-19T21:49:09.709Z","creation":"2025-04-19T21:49:09.709Z"},"accession":"S-EPMC8974676","cross_references":{"pubmed":["35386994"],"doi":["10.3389/falgy.2021.670789"]}}