biostudies-literatureUnknown2Datema MREuropean CommissionBackground: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanuFrontiers in allergy670789https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974676biostudies-literatureEstimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.PMC8974676Kowalski MLVieths SVassilopoulou ESinaniotis AFritsche PWelsing PMJMills ENCGislason DPopov TAde Blay FZwinderman AHHoffmann-Sommergruber KPapadopoulos NGClausen MFernandez-Perez CKralimarkova TZBelohlavkova SBarreales LVersteeg SAAsero RPurohit ABallmer-Weber BFernandez-Rivas MReig IJongejan LDatema MRKnulst ACJedrzejczak-Czechowicz MLidholm JDel Prado NLe TMLyons SADubakiene RSeneviratne SLvan Ree RfalseEstimating the Risk of Severe Peanut Allergy Using Clinical Background and IgE Sensitization Profiles.Background: It is not well-understood why symptom severity varies between patients with peanut allergy (PA). Objective: To gain insight into the clinical profile of subjects with mild-to-moderate and severe PA, and investigate individual and collective predictive accuracy of clinical background and IgE to peanut extract and components for PA severity. Methods: Data on demographics, patient history and sensitization at extract and component level of 393 patients with probable PA (symptoms ≤ 2 h + IgE sensitization) from 12 EuroPrevall centers were analyzed. Univariable and penalized multivariable regression analyses were used to evaluate risk factors and biomarkers for severity. Results: Female sex, age at onset of PA, symptoms elicited by skin contact with peanu2021-01-01T00:00:00Z20212025-04-19T21:49:09.709Z2025-04-19T21:49:09.709ZS-EPMC89746763538699410.3389/falgy.2021.670789