biostudies-literatureUnknown3Phelps AA series of landmark studies have provided conclusive evidence that the early administration of food allergens dramatically prevents the emergence of food allergy. One of the greatest remaining challenges is whether patients with established food allergy can return to health. This challenge is particularly pressing in the case of allergies against peanut, tree nuts, fish, and shellfish which are lifelong in most patients and may elicit severe reactions. The standard of care for food allergy is allergen avoidance and the timely administration of epinephrine upon accidental exposure. Epinephrine, and other therapeutic options like antihistamines provide acute symptom relief but do not target the underlying pathology of the disease. In principle, any transformative treatment for established fFrontiers in allergy826623https://www.ebi.ac.uk/biostudies/studies/S-EPMC8974751biostudies-literatureThe Road Toward Transformative Treatments for Food Allergy.PMC8974751Grydziuszko EPhelps AJordana MBruton KKoenig JFEfalseThe Road Toward Transformative Treatments for Food Allergy.A series of landmark studies have provided conclusive evidence that the early administration of food allergens dramatically prevents the emergence of food allergy. One of the greatest remaining challenges is whether patients with established food allergy can return to health. This challenge is particularly pressing in the case of allergies against peanut, tree nuts, fish, and shellfish which are lifelong in most patients and may elicit severe reactions. The standard of care for food allergy is allergen avoidance and the timely administration of epinephrine upon accidental exposure. Epinephrine, and other therapeutic options like antihistamines provide acute symptom relief but do not target the underlying pathology of the disease. In principle, any transformative treatment for established f2022-01-01T00:00:00Z20222025-05-29T19:46:40.779Z2025-04-05T20:53:06.431ZS-EPMC89747513538664210.3389/falgy.2022.826623