{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Tang S"],"pubmed_abstract":["<b>Background:</b> Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients. <b>Methods:</b> We conducted a systemic review and meta-analysis by searching multiple databases for studies from inception to October 2021. Outcomes of interest were the improved rate and safety of d-penicillamine and zinc salts treatment in WD patients. Two independent reviewers performed the study selection and data extraction. <b>Results:</b> Sixteen studies were included in this meta-analysis. The pooled improved rate for all included symptomatic WD patients was 78.0% (95% CI: 70.8%-85.2%). In symptomatic hepatic WD patients, there is no difference in the treatment effic"],"journal":["Frontiers in pharmacology"],"pagination":["847436"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8975209"],"repository":["biostudies-literature"],"pubmed_title":["Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta-Analysis."],"pmcid":["PMC8975209"],"pubmed_authors":["Liang C","Zhang W","Duan Z","Hu Z","Tang S","Zheng S","Bai L","Chen X","Zhao J","Hou W"],"additional_accession":[]},"is_claimable":false,"name":"Comparison of the Effectiveness and Safety of d-Penicillamine and Zinc Salt Treatment for Symptomatic Wilson Disease: A Systematic Review and Meta-Analysis.","description":"<b>Background:</b> Pharmacological therapy is currently the main treatment method for patients with Wilson disease (WD). We aimed to evaluate the efficacy and safety of the common treatment regimens in these patients. <b>Methods:</b> We conducted a systemic review and meta-analysis by searching multiple databases for studies from inception to October 2021. Outcomes of interest were the improved rate and safety of d-penicillamine and zinc salts treatment in WD patients. Two independent reviewers performed the study selection and data extraction. <b>Results:</b> Sixteen studies were included in this meta-analysis. The pooled improved rate for all included symptomatic WD patients was 78.0% (95% CI: 70.8%-85.2%). In symptomatic hepatic WD patients, there is no difference in the treatment effic","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-19T07:50:25.491Z","creation":"2025-04-19T07:50:25.491Z"},"accession":"S-EPMC8975209","cross_references":{"pubmed":["35370752"],"doi":["10.3389/fphar.2022.847436"]}}