{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Uma Reddy B"],"funding":["NIH HHS"],"pagination":["105512"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976571"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["168"],"pubmed_abstract":["<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches.<h4>Aim</h4>To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds.<h4>Methods</h4>Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry.<h4>Results</h4>The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered.<h4>Conclusion</h4>This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics."],"journal":["Microbial pathogenesis"],"pubmed_title":["Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2."],"pmcid":["PMC8976571"],"funding_grant_id":["P51 OD011132"],"pubmed_authors":["Uma Reddy B","Routhu NK","Kumar A"],"additional_accession":[]},"is_claimable":false,"name":"Multifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2.","description":"<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches.<h4>Aim</h4>To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds.<h4>Methods</h4>Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry.<h4>Results</h4>The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered.<h4>Conclusion</h4>This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jul","modification":"2026-05-31T06:04:25.836Z","creation":"2025-02-19T01:55:21.206Z"},"accession":"S-EPMC8976571","cross_references":{"pubmed":["35381324"],"doi":["10.1016/j.micpath.2022.105512"]}}