biostudies-literatureUma Reddy BNIH HHS105512https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976571biostudies-literatureUnknown168<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches.<h4>Aim</h4>To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds.<h4>Methods</h4>Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry.<h4>Results</h4>The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered.<h4>Conclusion</h4>This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics.Microbial pathogenesisMultifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2.PMC8976571P51 OD011132Uma Reddy BRouthu NKKumar AfalseMultifaceted roles of plant derived small molecule inhibitors on replication cycle of SARS-CoV-2.<h4>Introduction</h4>Coronavirus disease 2019 (COVID-19) is an illness caused by the new coronavirus severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2). It has affected public health and the economy globally. Currently approved vaccines and other drug candidates could be associated with several drawbacks which urges developing alternative therapeutic approaches.<h4>Aim</h4>To provide a comprehensive review of anti-SARS-CoV-2 activities of plants and their bioactive compounds.<h4>Methods</h4>Information was gathered from diverse bibliographic platforms such as PubMed, Google Scholar, and ClinicalTrials.gov registry.<h4>Results</h4>The present review highlights the potential roles of crude extracts of plants as well as plant-derived small molecules in inhibiting SARS-CoV-2 infection by targeting viral or host factors essential for viral entry, polyprotein processing, replication, assembly and release. Their anti-inflammatory and antioxidant properties as well as plant-based therapies that are under development in the clinical trial phases-1 to 3 are also covered.<h4>Conclusion</h4>This knowledge could further help understanding SARS-CoV-2 infection and anti-viral mechanisms of plant-based therapeutics.2022-01-01T00:00:00Z2022 Jul2026-05-31T06:04:25.836Z2025-02-19T01:55:21.206ZS-EPMC89765713538132410.1016/j.micpath.2022.105512