biostudies-literatureUnknown11(3)Mei T<h4>Background</h4>Autism spectrum disorder is characterized by atypical developmental changes during brain maturation, but regional brain functional changes that occur with age and across different frequency bands are unknown. Therefore, the current study aimed to explore potential age and frequency band-related changes in the regional brain activities in autism.<h4>Methods</h4>A total of 65 participants who met the DSM-IV criteria for autistic disorder and 55 typically developed (TD) participants (both age 6-30 years) were recruited in the current study. The two groups were matched in age (t=-1.314, P=0.191) and gender (χ²=2.760, P=0.097). The amplitude of low-frequency fluctuations (ALFF) was employed to explore the effect of development on spontaneous brain activity in indivTranslational pediatrics349-358https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976680biostudies-literatureFrequency-specific age-related changes in the amplitude of spontaneous fluctuations in autism.PMC8976680Ji ZZLiu JWang LQYang LMei TWang HLu BLi XTang XZMa ZHCao QJYan CGChen XGuo YQXu LZYang YLLiu JRfalseFrequency-specific age-related changes in the amplitude of spontaneous fluctuations in autism.<h4>Background</h4>Autism spectrum disorder is characterized by atypical developmental changes during brain maturation, but regional brain functional changes that occur with age and across different frequency bands are unknown. Therefore, the current study aimed to explore potential age and frequency band-related changes in the regional brain activities in autism.<h4>Methods</h4>A total of 65 participants who met the DSM-IV criteria for autistic disorder and 55 typically developed (TD) participants (both age 6-30 years) were recruited in the current study. The two groups were matched in age (t=-1.314, P=0.191) and gender (χ²=2.760, P=0.097). The amplitude of low-frequency fluctuations (ALFF) was employed to explore the effect of development on spontaneous brain activity in indiv2022-01-01T00:00:00Z2022 Mar2025-04-05T16:07:11.403Z2025-04-05T16:07:11.403ZS-EPMC89766803537896310.21037/tp-21-412