{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tran TT"],"funding":["NIA NIH HHS","U.S. Department of Defense","National Institutes of Health","National Defense Science and Engineering Graduate","National Institute on Aging","Air Force Office of Scientific Research"],"pagination":["151-160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976714"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["112"],"pubmed_abstract":["The entorhinal cortex is the site of some of the earliest pathological changes in Alzheimer's disease, including neuronal, synaptic and volumetric loss. Specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (aMCI) phase of Alzheimer's disease. Although decreased entorhinal cortex activation has been observed in patients with aMCI in the context of impaired memory function, it remains unclear if functional changes in the entorhinal cortex can be localized to the lateral or medial entorhinal cortex. To assess subregion specific changes in the lateral and medial entorhinal cortex, patients with aMCI and healthy aged-matched control participants underwent high-resolution structural and functional magn"],"journal":["Neurobiology of aging"],"pubmed_title":["Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment."],"pmcid":["PMC8976714"],"funding_grant_id":["RC2 AG036419","RO1AG048349","P50 AG005146","P50AG05146","R01 AG048349","RC2AG036419","32 CFR 168a"],"pubmed_authors":["Speck CL","Gallagher M","Tran TT","Bakker A"],"additional_accession":[]},"is_claimable":false,"name":"Lateral entorhinal cortex dysfunction in amnestic mild cognitive impairment.","description":"The entorhinal cortex is the site of some of the earliest pathological changes in Alzheimer's disease, including neuronal, synaptic and volumetric loss. Specifically, the lateral entorhinal cortex shows significant accumulation of tau neurofibrillary tangles in the amnestic mild cognitive impairment (aMCI) phase of Alzheimer's disease. Although decreased entorhinal cortex activation has been observed in patients with aMCI in the context of impaired memory function, it remains unclear if functional changes in the entorhinal cortex can be localized to the lateral or medial entorhinal cortex. To assess subregion specific changes in the lateral and medial entorhinal cortex, patients with aMCI and healthy aged-matched control participants underwent high-resolution structural and functional magn","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-19T13:29:52.883Z","creation":"2025-04-19T13:29:52.883Z"},"accession":"S-EPMC8976714","cross_references":{"pubmed":["35182842"],"doi":["10.1016/j.neurobiolaging.2021.12.008"]}}