{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sawada J"],"funding":["National Cancer Institute","NCI NIH HHS","Florida Department of Health","Florida Breast Cancer Foundation"],"pagination":["468-481"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976767"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(4)"],"pubmed_abstract":["High endothelial venules (HEV) are specialized post-capillary venules that recruit naïve lymphocytes to lymph nodes. HEVs are essential for the development of adaptive immunity. HEVs can also develop in tumors where they are thought to be important for recruiting naïve T cells and B cells into the tumors and locally enhancing antitumor immunity by supporting the formation of tertiary lymphoid structures. Herein, we used comparative transcriptome analysis of human breast cancer to investigate genes differentially expressed between tumor-associated HEVs and the rest of the tumor vasculature. Tumor vessels highly expressing HEV-upregulated genes, such as the homeobox gene MEOX2 and the tetraspanin gene TSPAN7, were associated with extensive infiltration of T and B cells and the occurrence of "],"journal":["Cancer immunology research"],"pubmed_title":["Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival."],"pmcid":["PMC8976767"],"funding_grant_id":["20B01","R01CA125255","R01 CA125255"],"pubmed_authors":["Yoshida M","Jiang L","Kawashima H","Hiraoka N","Sawada J","Qi R","Fournier-Goss AE","Komatsu M"],"additional_accession":[]},"is_claimable":false,"name":"Molecular Signature of Tumor-Associated High Endothelial Venules That Can Predict Breast Cancer Survival.","description":"High endothelial venules (HEV) are specialized post-capillary venules that recruit naïve lymphocytes to lymph nodes. HEVs are essential for the development of adaptive immunity. HEVs can also develop in tumors where they are thought to be important for recruiting naïve T cells and B cells into the tumors and locally enhancing antitumor immunity by supporting the formation of tertiary lymphoid structures. Herein, we used comparative transcriptome analysis of human breast cancer to investigate genes differentially expressed between tumor-associated HEVs and the rest of the tumor vasculature. Tumor vessels highly expressing HEV-upregulated genes, such as the homeobox gene MEOX2 and the tetraspanin gene TSPAN7, were associated with extensive infiltration of T and B cells and the occurrence of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2026-07-14T14:25:31.844Z","creation":"2025-04-04T23:37:12.317Z"},"accession":"S-EPMC8976767","cross_references":{"pubmed":["35201289"],"doi":["10.1158/2326-6066.CIR-21-0369"]}}