{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["37(2)"],"submitter":["Syarifah S"],"pubmed_abstract":["<h4>Objectives</h4>Hematological toxicity induced by chemotherapy is known to be caused by multiple factors, including genetic factors such as polymorphisms. The polymorphisms may occur in drug efflux transporter proteins and enzymes involved in drug metabolism. We investigate the incidence of hematological toxicities and their relation to the haplotype ATP-binding cassette B1 (ABCB1) which were polymorphisms of <i>C1236T</i>, <i>C3435T</i>, <i>G2677T,</i> and glutathione S-transferase P1 (<i>GSTP1</i>) <i>A313G</i> genes in Indonesian breast cancer patients who received anthracycline during chemotherapy.<h4>Methods</h4>This retrospective cohort study was conducted on 138 breast cancer patients who underwent three cycles of chemotherapy in H. Adam Malik Hospital, Medan, Indonesia, who sati"],"journal":["Oman medical journal"],"pagination":["e357"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976885"],"repository":["biostudies-literature"],"pubmed_title":["The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 <i>A313G</i> Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy."],"pmcid":["PMC8976885"],"pubmed_authors":["Widyawati T","Syarifah S","Sari MI","Hasni D","Hamdi T","Rusdiana R"],"additional_accession":[]},"is_claimable":false,"name":"The Relation of Haplotype ATP-binding Cassette B1 and Glutathione S-transferase P1 <i>A313G</i> Genes with Hematological Toxicity in Indonesian Breast Cancer Patients Receiving Chemotherapy.","description":"<h4>Objectives</h4>Hematological toxicity induced by chemotherapy is known to be caused by multiple factors, including genetic factors such as polymorphisms. The polymorphisms may occur in drug efflux transporter proteins and enzymes involved in drug metabolism. We investigate the incidence of hematological toxicities and their relation to the haplotype ATP-binding cassette B1 (ABCB1) which were polymorphisms of <i>C1236T</i>, <i>C3435T</i>, <i>G2677T,</i> and glutathione S-transferase P1 (<i>GSTP1</i>) <i>A313G</i> genes in Indonesian breast cancer patients who received anthracycline during chemotherapy.<h4>Methods</h4>This retrospective cohort study was conducted on 138 breast cancer patients who underwent three cycles of chemotherapy in H. Adam Malik Hospital, Medan, Indonesia, who sati","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T12:44:35.867Z","creation":"2025-04-04T12:44:35.867Z"},"accession":"S-EPMC8976885","cross_references":{"pubmed":["35402005"],"doi":["10.5001/omj.2022.36"]}}