biostudies-literatureZhao TInnovative Research Group Project of the National Natural Science Foundation of ChinaNatural Science Foundation of Hebei ProvincePostdoctoral Research Foundation of ChinaNational Natural Science Foundation of China177https://www.ebi.ac.uk/biostudies/studies/S-EPMC8976966biostudies-literatureUnknown20(1)<h4>Background</h4>Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While the widely application of siRNAs in cancer treatment is severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold great promise to selectively deliver loaded drug to tumor site and reduce toxic side effect. However, the elevated tumor interstitial fluid pressure and efficient cytoplasmic release are still two significant obstacles to siRNA delivery. Co-delivery of chemotherapeutic drugs and siRNA represents a potential strategy which may achieve synergistic anticancer effect. Herein, we designed and synthesized a dual pH-responsive peptide Journal of nanobiotechnologyMultistage pH-responsive codelivery liposomal platform for synergistic cancer therapy.PMC8976966817736668197325182071533H2019206434H2019206445H20202064742015T80228Du QQi JZhang JZhang HCao DMa ZZhao TShen HZhao YXue XLiang CJia QXiang BQi XYang SfalseMultistage pH-responsive codelivery liposomal platform for synergistic cancer therapy.<h4>Background</h4>Small interfering RNA (siRNA) is utilized as a potent agent for cancer therapy through regulating the expression of genes associated with tumors. While the widely application of siRNAs in cancer treatment is severely limited by their insufficient biological stability and its poor ability to penetrate cell membranes. Targeted delivery systems hold great promise to selectively deliver loaded drug to tumor site and reduce toxic side effect. However, the elevated tumor interstitial fluid pressure and efficient cytoplasmic release are still two significant obstacles to siRNA delivery. Co-delivery of chemotherapeutic drugs and siRNA represents a potential strategy which may achieve synergistic anticancer effect. Herein, we designed and synthesized a dual pH-responsive peptide 2022-01-01T00:00:00Z2022 Apr2025-04-26T18:28:39.475Z2025-04-06T15:49:18.551ZS-EPMC89769663536688810.1186/s12951-022-01383-z