{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Fuentes MA"],"funding":["American Cancer Society","NIDDK NIH HHS","National Institute of General Medical Sciences","NIGMS NIH HHS"],"pagination":["dev200468"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977094"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["149(6)"],"pubmed_abstract":["Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains unknown whether additional mechanical inputs are required for apical constriction-mediated folding. Using Drosophila mesoderm invagination as a model, we identified an important role for the non-constricting, lateral mesodermal cells adjacent to the constriction domain ('flanking cells') in facilitating epithelial folding. We found that depletion of the basolateral determinant Dlg1 disrupts the transition between apical constriction and invagination without affecting the rate of apical constriction. Strikingly, the observed delay in invagination is associated with ineffective apical myosin contractions in the flanking cells that lea"],"journal":["Development (Cambridge, England)"],"pubmed_title":["The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination."],"pmcid":["PMC8977094"],"funding_grant_id":["R35GM128745","R35 GM128745","P20 GM113132","P30 DK117469","IRG-16-191-33"],"pubmed_authors":["Fuentes MA","He B"],"additional_accession":[]},"is_claimable":false,"name":"The cell polarity determinant Dlg1 facilitates epithelial invagination by promoting tissue-scale mechanical coordination.","description":"Epithelial folding mediated by apical constriction serves as a fundamental mechanism to convert flat epithelial sheets into multilayered structures. It remains unknown whether additional mechanical inputs are required for apical constriction-mediated folding. Using Drosophila mesoderm invagination as a model, we identified an important role for the non-constricting, lateral mesodermal cells adjacent to the constriction domain ('flanking cells') in facilitating epithelial folding. We found that depletion of the basolateral determinant Dlg1 disrupts the transition between apical constriction and invagination without affecting the rate of apical constriction. Strikingly, the observed delay in invagination is associated with ineffective apical myosin contractions in the flanking cells that lea","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T21:30:57.273Z","creation":"2025-04-04T21:30:57.273Z"},"accession":"S-EPMC8977094","cross_references":{"pubmed":["35302584"],"doi":["10.1242/dev.200468"]}}