{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kronzer VL"],"funding":["NHLBI NIH HHS","NIAMS NIH HHS"],"pagination":["358-364"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977280"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["49(4)"],"pubmed_abstract":["<h4>Objective</h4>We aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk.<h4>Methods</h4>This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases to 3 controls on age, sex, and electronic health record history. We identified RA using a validated algorithm and confirmed by medical record review. Respiratory tract disease exposure required 1 inpatient or 2 outpatient codes at least 2 years before the index date of RA clinical diagnosis or matched date. Logistic regression models calculated ORs for RA with 95% CIs, adjusting for confounders. We then stratified by serostatus (\"seropositive\" was positive rheumatoid factor and/or anticitrullinated protein antibodies) and smoking.<h4>Results</h4>We identified 741 RA cases and 2223 controls (both median age 55, 76% female). Acute sinusitis (OR 1.61, 95% CI 1.05-2.45), chronic sinusitis (OR 2.16, 95% CI 1.39-3.35), and asthma (OR 1.39, 95% CI 1.03-1.87) were associated with increased risk of RA. Acute respiratory tract disease burden during the preindex exposure period was also associated with increased RA risk (OR 1.30 per 10 codes, 95% CI 1.08-1.55). Acute pharyngitis was associated with seronegative (OR 1.68, 95% CI 1.02-2.74) but not seropositive RA; chronic rhinitis/pharyngitis was associated with seropositive (OR 2.46, 95% CI 1.01-5.99) but not seronegative RA. Respiratory tract diseases tended towards higher associations in smokers, especially > 10 pack-years (OR 1.52, 95% CI 1.02-2.27, <i>P</i> = 0.10 for interaction).<h4>Conclusion</h4>Acute and chronic sinusitis, pharyngitis, and acute respiratory burden increased RA risk. The mucosal paradigm of RA pathogenesis may involve the upper respiratory tract."],"journal":["The Journal of rheumatology"],"pubmed_title":["Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study."],"pmcid":["PMC8977280"],"funding_grant_id":["R03 HL148484","K23 AR069688","P30 AR072577","L30 AR066953","P30 AR070253","R03 AR075886"],"pubmed_authors":["Sparks JA","Doyle TJ","Crowson CS","Vassallo R","Davis JM","Losina E","Kronzer VL","Huang W","Zaccardelli A"],"additional_accession":[]},"is_claimable":false,"name":"Association of Sinusitis and Upper Respiratory Tract Diseases With Incident Rheumatoid Arthritis: A Case-control Study.","description":"<h4>Objective</h4>We aimed to determine whether specific respiratory tract diseases are associated with increased rheumatoid arthritis (RA) risk.<h4>Methods</h4>This case-control study within the Mass General Brigham Biobank matched newly diagnosed RA cases to 3 controls on age, sex, and electronic health record history. We identified RA using a validated algorithm and confirmed by medical record review. Respiratory tract disease exposure required 1 inpatient or 2 outpatient codes at least 2 years before the index date of RA clinical diagnosis or matched date. Logistic regression models calculated ORs for RA with 95% CIs, adjusting for confounders. We then stratified by serostatus (\"seropositive\" was positive rheumatoid factor and/or anticitrullinated protein antibodies) and smoking.<h4>Results</h4>We identified 741 RA cases and 2223 controls (both median age 55, 76% female). Acute sinusitis (OR 1.61, 95% CI 1.05-2.45), chronic sinusitis (OR 2.16, 95% CI 1.39-3.35), and asthma (OR 1.39, 95% CI 1.03-1.87) were associated with increased risk of RA. Acute respiratory tract disease burden during the preindex exposure period was also associated with increased RA risk (OR 1.30 per 10 codes, 95% CI 1.08-1.55). Acute pharyngitis was associated with seronegative (OR 1.68, 95% CI 1.02-2.74) but not seropositive RA; chronic rhinitis/pharyngitis was associated with seropositive (OR 2.46, 95% CI 1.01-5.99) but not seronegative RA. Respiratory tract diseases tended towards higher associations in smokers, especially > 10 pack-years (OR 1.52, 95% CI 1.02-2.27, <i>P</i> = 0.10 for interaction).<h4>Conclusion</h4>Acute and chronic sinusitis, pharyngitis, and acute respiratory burden increased RA risk. The mucosal paradigm of RA pathogenesis may involve the upper respiratory tract.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Apr","modification":"2025-04-22T11:46:39.985Z","creation":"2025-04-06T00:07:27.784Z"},"accession":"S-EPMC8977280","cross_references":{"pubmed":["34654732"],"doi":["10.3899/jrheum.210580"]}}