{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu L"],"funding":["Foundation of Zhejiang Health Science and Technology"],"pagination":["1172795"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977338"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["<i>β</i> cell dysfunction is the leading cause of diabetes. Adult <i>β</i> cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal <i>β</i> cells are insensitive to glucose and are functionally immature. However, how <i>β</i> cells mature and acquire robust GSIS is not fully understood. Here, we explored the potential regulatory proteins of <i>β</i> cell maturation process and the capacity for GSIS. Combined with the data from public databases, we found that the gene expression of <i>Mitofusin2</i> (<i>Mfn2</i>) showed an increasing trend from mouse neonatal <i>β</i> cells to mature <i>β</i> cells. Moreover, its protein expression increased during mouse embryonic pancreas development and <i>β</i> cell differentiation from mouse embryonic stem cells. Knock"],"journal":["Stem cells international"],"pubmed_title":["Mitofusin2 Promotes <i>β</i> Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation."],"pmcid":["PMC8977338"],"funding_grant_id":["LYY21H310003","LYY20H280004","2020381061","81703578"],"pubmed_authors":["Lu L","Dongsheng H","Mingzhu H","Zongfu P","Xiaoyang L","Xiaoping H","Nannan C","Zhitao L"],"additional_accession":[]},"is_claimable":false,"name":"Mitofusin2 Promotes <i>β</i> Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation.","description":"<i>β</i> cell dysfunction is the leading cause of diabetes. Adult <i>β</i> cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal <i>β</i> cells are insensitive to glucose and are functionally immature. However, how <i>β</i> cells mature and acquire robust GSIS is not fully understood. Here, we explored the potential regulatory proteins of <i>β</i> cell maturation process and the capacity for GSIS. Combined with the data from public databases, we found that the gene expression of <i>Mitofusin2</i> (<i>Mfn2</i>) showed an increasing trend from mouse neonatal <i>β</i> cells to mature <i>β</i> cells. Moreover, its protein expression increased during mouse embryonic pancreas development and <i>β</i> cell differentiation from mouse embryonic stem cells. Knock","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-06-18T08:48:40.153Z","creation":"2025-04-19T21:50:11.352Z"},"accession":"S-EPMC8977338","cross_references":{"pubmed":["35386849"],"doi":["10.1155/2022/1172795"]}}