biostudies-literatureLu LFoundation of Zhejiang Health Science and Technology1172795https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977338biostudies-literatureUnknown2022<i>β</i> cell dysfunction is the leading cause of diabetes. Adult <i>β</i> cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal <i>β</i> cells are insensitive to glucose and are functionally immature. However, how <i>β</i> cells mature and acquire robust GSIS is not fully understood. Here, we explored the potential regulatory proteins of <i>β</i> cell maturation process and the capacity for GSIS. Combined with the data from public databases, we found that the gene expression of <i>Mitofusin2</i> (<i>Mfn2</i>) showed an increasing trend from mouse neonatal <i>β</i> cells to mature <i>β</i> cells. Moreover, its protein expression increased during mouse embryonic pancreas development and <i>β</i> cell differentiation from mouse embryonic stem cells. KnockStem cells internationalMitofusin2 Promotes <i>β</i> Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation.PMC8977338LYY21H310003LYY20H280004202038106181703578Lu LDongsheng HMingzhu HZongfu PXiaoyang LXiaoping HNannan CZhitao LfalseMitofusin2 Promotes <i>β</i> Cell Maturation from Mouse Embryonic Stem Cells via Sirt3/Idh2 Activation.<i>β</i> cell dysfunction is the leading cause of diabetes. Adult <i>β</i> cells have matured glucose-stimulated insulin secretion (GSIS), whereas fetal and neonatal <i>β</i> cells are insensitive to glucose and are functionally immature. However, how <i>β</i> cells mature and acquire robust GSIS is not fully understood. Here, we explored the potential regulatory proteins of <i>β</i> cell maturation process and the capacity for GSIS. Combined with the data from public databases, we found that the gene expression of <i>Mitofusin2</i> (<i>Mfn2</i>) showed an increasing trend from mouse neonatal <i>β</i> cells to mature <i>β</i> cells. Moreover, its protein expression increased during mouse embryonic pancreas development and <i>β</i> cell differentiation from mouse embryonic stem cells. Knock2022-01-01T00:00:00Z20222026-06-18T08:48:40.153Z2025-04-19T21:50:11.352ZS-EPMC89773383538684910.1155/2022/1172795