biostudies-literatureMa JNational Natural Science Foundation of ChinaNational key research and development program4th Three-year Action Plan for Public Health of ShanghaiShanghai Pujiang ProgramShanghai Key Laboratory of Psychotic Disorders1780-1790https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977635biostudies-literatureUnknown19(10)<h4>Background</h4>Catechol-O-methyltransferase (COMT) contributes to the control of synaptic dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The COMT Val158Met polymorphism (rs4680) substantially alters enzymatic activity and consequently synaptic DA concentration in the prefrontal cortex and hippocampus. The COMT genotype could, therefore, exert a major influence on antipsychotic treatment response as many of these agents also target dopaminergic transmission.<h4>Objective</h4>The present meta-analysis aimed to test a putative relationship between the COMT Val158Met polymorphism and antipsychotic response across different populations and antipsychotic types.<h4>Methods</h4>Searches of PubMed, Web of Science, EMBASE, OVID, Google Scholar, and Baidu ScholaCurrent neuropharmacologyAssociation Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.PMC897763581773818, 81273596, 30900799, 81671326817738182016YFC09064002016YFC090500217PJD02015GWZK01012016YFC12002002016YFC090500081671326812735962016YFC0905000, 2016YFC0905002, 2016YFC1200200, 2016YFC090640013DZ226050030900799Shen LZhao MHuai CZhang ZWang TZhang NMa JZhou WHe LLi MWu HQin SfalseAssociation Between the COMT Val158Met Polymorphism and Antipsychotic Efficacy in Schizophrenia: An Updated Meta-Analysis.<h4>Background</h4>Catechol-O-methyltransferase (COMT) contributes to the control of synaptic dopamine (DA) transmission by catalyzing DA degradation in the presynaptic space. The COMT Val158Met polymorphism (rs4680) substantially alters enzymatic activity and consequently synaptic DA concentration in the prefrontal cortex and hippocampus. The COMT genotype could, therefore, exert a major influence on antipsychotic treatment response as many of these agents also target dopaminergic transmission.<h4>Objective</h4>The present meta-analysis aimed to test a putative relationship between the COMT Val158Met polymorphism and antipsychotic response across different populations and antipsychotic types.<h4>Methods</h4>Searches of PubMed, Web of Science, EMBASE, OVID, Google Scholar, and Baidu Schola2021-01-01T00:00:00Z20212026-05-09T20:11:03.54Z2025-02-19T00:56:40.718ZS-EPMC89776353310020510.2174/1570159X18666201023154049