biostudies-literatureUnknown13(2)Kiefer LS<h4>Background</h4>Skeletal muscle mass is subjected to constant changes and is considered a good predictor for outcome in various diseases. Bioelectrical-impedance analysis (BIA) and magnetic resonance imaging (MRI) are approved methodologies for its assessment. However, muscle mass estimations by BIA may be influenced by excess intramuscular lipids and adipose tissue in obesity. The objective of this study was to evaluate the feasibility of quantitative assessment of skeletal muscle mass by MRI as compared with BIA.<h4>Methods</h4>Subjects from a population-based cohort underwent BIA (50 kHz, 0.8 mA) and whole-body MRI including chemical-shift encoded MRI (six echo times). Abdominal muscle mass by MRI was quantified as total and fat-free cross-sectional area by a standardized manual segmJournal of cachexia, sarcopenia and muscle976-986https://www.ebi.ac.uk/biostudies/studies/S-EPMC8977960biostudies-literaturePopulation-based cohort imaging: skeletal muscle mass by magnetic resonance imaging in correlation to bioelectrical-impedance analysis.PMC8977960Machann JRathmann WLorbeer RPeters AKraus MSRoemer FFabian JMeisinger CSchlett CLStorz CBamberg FRospleszcz SKiefer LSHeier MFischer MNikolaou KfalsePopulation-based cohort imaging: skeletal muscle mass by magnetic resonance imaging in correlation to bioelectrical-impedance analysis.<h4>Background</h4>Skeletal muscle mass is subjected to constant changes and is considered a good predictor for outcome in various diseases. Bioelectrical-impedance analysis (BIA) and magnetic resonance imaging (MRI) are approved methodologies for its assessment. However, muscle mass estimations by BIA may be influenced by excess intramuscular lipids and adipose tissue in obesity. The objective of this study was to evaluate the feasibility of quantitative assessment of skeletal muscle mass by MRI as compared with BIA.<h4>Methods</h4>Subjects from a population-based cohort underwent BIA (50 kHz, 0.8 mA) and whole-body MRI including chemical-shift encoded MRI (six echo times). Abdominal muscle mass by MRI was quantified as total and fat-free cross-sectional area by a standardized manual segm2022-01-01T00:00:00Z2022 Apr2025-04-25T23:02:08.984Z2025-04-06T09:13:07.24ZS-EPMC89779603508014110.1002/jcsm.12913