biostudies-literatureDemidenko MINICHD NIH HHSNational Institute on Alcohol Abuse and AlcoholismNIDA NIH HHSJacobs FoundationNIAAA NIH HHSEunice Kennedy Shriver National Institute of Child Health & Human DevelopmentNational Institute on Drug Abuse762-779https://www.ebi.ac.uk/biostudies/studies/S-EPMC8978150biostudies-literatureUnknown100(3)Adolescent risk-taking, including sensation seeking (SS), is often attributed to developmental changes in connectivity among brain regions implicated in cognitive control and reward processing. Despite considerable scientific and popular interest in this neurodevelopmental framework, there are few empirical investigations of adolescent functional connectivity, let alone examinations of its links to SS behavior. The studies that have been done focus on mean-based approaches and leave unanswered questions about individual differences in neurodevelopment and behavior. The goal of this paper is to take a person-specific approach to the study of adolescent functional connectivity during a continuous motivational state, and to examine links between connectivity and self-reported SS behavior in 1Journal of neuroscience researchNeural heterogeneity underlying late adolescent motivational processing is linked to individual differences in behavioral sensation seeking.PMC8978150K23 DA051561R01 HD075806T32 AA007477R01HD075806T32 HD007109Keating DPBeltz AMHuntley EDWeigard ASDemidenko MIfalseNeural heterogeneity underlying late adolescent motivational processing is linked to individual differences in behavioral sensation seeking.Adolescent risk-taking, including sensation seeking (SS), is often attributed to developmental changes in connectivity among brain regions implicated in cognitive control and reward processing. Despite considerable scientific and popular interest in this neurodevelopmental framework, there are few empirical investigations of adolescent functional connectivity, let alone examinations of its links to SS behavior. The studies that have been done focus on mean-based approaches and leave unanswered questions about individual differences in neurodevelopment and behavior. The goal of this paper is to take a person-specific approach to the study of adolescent functional connectivity during a continuous motivational state, and to examine links between connectivity and self-reported SS behavior in 12022-01-01T00:00:00Z2022 Mar2025-04-05T15:52:44.967Z2025-04-05T15:52:44.967ZS-EPMC89781503504344810.1002/jnr.25005