{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Ping YH"],"pubmed_abstract":["COVID-19 is a global epidemic. Developing adjuvant therapies which could prevent the virus from binding to cells may impair viral infection. This study produces a traditional Chinese medicine formula, Jing Guan Fang (JGF), based on ancient medical texts, and examines the efficacy and the mechanism by which JGF prevents viral infections. JGF reduces COVID-19 like symptoms. Functional studies show that JGF inhibits the formation of syncytium and reduces the formation of viral plaque. JGF is not toxic <i>in vitro</i> and <i>in vivo</i>. Mechanistically, JGF induces lysosomal-dependent ACE2 degradation and suppresses mRNA and the protein levels of TMPRSS2 in human lung WI-38 and MRC-5 cells. Mice that inhale JGF exhibit reduced ACE2 and TMPRSS2 protein levels in lung tissues. Together, these f"],"journal":["Frontiers in pharmacology"],"pagination":["744439"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8978714"],"repository":["biostudies-literature"],"pubmed_title":["The Traditional Chinese Medicine Formula Jing Guan Fang for Preventing SARS-CoV-2 Infection: From Clinical Observation to Basic Research."],"pmcid":["PMC8978714"],"pubmed_authors":["Ping YH","Yeh H","Lin ZH","Hsu YC","Chu LW","Fu SL","Lin LC","Hsu CH","Lin TY"],"additional_accession":[]},"is_claimable":false,"name":"The Traditional Chinese Medicine Formula Jing Guan Fang for Preventing SARS-CoV-2 Infection: From Clinical Observation to Basic Research.","description":"COVID-19 is a global epidemic. Developing adjuvant therapies which could prevent the virus from binding to cells may impair viral infection. This study produces a traditional Chinese medicine formula, Jing Guan Fang (JGF), based on ancient medical texts, and examines the efficacy and the mechanism by which JGF prevents viral infections. JGF reduces COVID-19 like symptoms. Functional studies show that JGF inhibits the formation of syncytium and reduces the formation of viral plaque. JGF is not toxic <i>in vitro</i> and <i>in vivo</i>. Mechanistically, JGF induces lysosomal-dependent ACE2 degradation and suppresses mRNA and the protein levels of TMPRSS2 in human lung WI-38 and MRC-5 cells. Mice that inhale JGF exhibit reduced ACE2 and TMPRSS2 protein levels in lung tissues. Together, these f","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-05-31T21:02:33.741Z","creation":"2025-04-04T21:43:15.561Z"},"accession":"S-EPMC8978714","cross_references":{"pubmed":["35387343"],"doi":["10.3389/fphar.2022.744439"]}}