{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Qi H"],"funding":["National Natural Science Foundation of China"],"pagination":["1989-1997"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8979007"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(4)"],"pubmed_abstract":["Using aurine and citric acid as precursors, we have synthesized stable blue-fluorescent nitrogen and sulfur co-doped carbon dots (NS-CDs), with a high quantum yield of up to 68.94% <i>via</i> a thermal lysis method. The fluorescent NS-CDs were employed as a sensitive sensor for the integration detection of Hg<sup>2+</sup> and glutathione (GSH). This was attributed to Hg<sup>2+</sup> effectively quenching the fluorescence of the NS-CDs by static quenching, and then GSH was able to recover the fluorescence owing to the stronger binding between Hg<sup>2+</sup> and the sulfhydryl of GSH. Based on the \"on-off-on\" tactic, the detection limits of Hg<sup>2+</sup> ions and GSH were 50 nM and 67 nM respectively. The fluorescence sensor was successfully applied to detect Hg<sup>2+</sup> ions and GSH in actual samples (tap water and fetal bovine serum). Furthermore, we have proved that the sensor had good reversibility. Overall, our NS-CDs can serve as effective sensors for environmental and biological analysis in the future."],"journal":["RSC advances"],"pubmed_title":["Integration detection of mercury(ii) and GSH with a fluorescent \"on-off-on\" switch sensor based on nitrogen, sulfur co-doped carbon dots."],"pmcid":["PMC8979007"],"funding_grant_id":["52172092"],"pubmed_authors":["Li J","Qi H","Sun X","Jing T"],"additional_accession":[]},"is_claimable":false,"name":"Integration detection of mercury(ii) and GSH with a fluorescent \"on-off-on\" switch sensor based on nitrogen, sulfur co-doped carbon dots.","description":"Using aurine and citric acid as precursors, we have synthesized stable blue-fluorescent nitrogen and sulfur co-doped carbon dots (NS-CDs), with a high quantum yield of up to 68.94% <i>via</i> a thermal lysis method. The fluorescent NS-CDs were employed as a sensitive sensor for the integration detection of Hg<sup>2+</sup> and glutathione (GSH). This was attributed to Hg<sup>2+</sup> effectively quenching the fluorescence of the NS-CDs by static quenching, and then GSH was able to recover the fluorescence owing to the stronger binding between Hg<sup>2+</sup> and the sulfhydryl of GSH. Based on the \"on-off-on\" tactic, the detection limits of Hg<sup>2+</sup> ions and GSH were 50 nM and 67 nM respectively. The fluorescence sensor was successfully applied to detect Hg<sup>2+</sup> ions and GSH in actual samples (tap water and fetal bovine serum). Furthermore, we have proved that the sensor had good reversibility. Overall, our NS-CDs can serve as effective sensors for environmental and biological analysis in the future.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-22T13:13:26.284Z","creation":"2025-02-19T01:23:13.099Z"},"accession":"S-EPMC8979007","cross_references":{"pubmed":["35425249"],"doi":["10.1039/d1ra08890d"]}}