biostudies-literatureUnknown9Wertenauer C<h4>Background</h4>Rapid diagnostic testing for SARS-Cov-2 antigens is used to combat the ongoing pandemic. In this study we aimed to compare two RDTs, the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche) and the Panbio COVID-19 Ag Rapid Test (Abbott), against rRT-PCR.<h4>Methods</h4>We included 2,215 all-comers at a diagnostic center between February 1 and March 31, 2021. rRT-PCR-positive samples were examined for SARS-CoV-2 variants.<h4>Findings</h4>Three hundred and thirty eight participants (15%) were rRT-PCR-positive for SARS-CoV-2. The sensitivities of Roche-RDT and Abbott-RDT were 60.4 and 56.8% (<i>P</i> < 0.0001) and specificities 99.7% and 99.8% (<i>P</i> = 0.076). Sensitivity inversely correlated with rRT-PCR-Ct values. The RDTs had higher sensitivities in individuals referrFrontiers in medicine774550https://www.ebi.ac.uk/biostudies/studies/S-EPMC8979030biostudies-literatureDiagnostic Performance of Rapid Antigen Testing for SARS-CoV-2: The COVid-19 AntiGen (COVAG) study.PMC8979030Marz WMutschmann CMoissl APHauser UWertenauer CWieland EMayer CWertenauer HJBrenner Michael GRoskos MDressel APfeifer CLorkowski SfalseDiagnostic Performance of Rapid Antigen Testing for SARS-CoV-2: The COVid-19 AntiGen (COVAG) study.<h4>Background</h4>Rapid diagnostic testing for SARS-Cov-2 antigens is used to combat the ongoing pandemic. In this study we aimed to compare two RDTs, the SD Biosensor Q SARS-CoV-2 Rapid Antigen Test (Roche) and the Panbio COVID-19 Ag Rapid Test (Abbott), against rRT-PCR.<h4>Methods</h4>We included 2,215 all-comers at a diagnostic center between February 1 and March 31, 2021. rRT-PCR-positive samples were examined for SARS-CoV-2 variants.<h4>Findings</h4>Three hundred and thirty eight participants (15%) were rRT-PCR-positive for SARS-CoV-2. The sensitivities of Roche-RDT and Abbott-RDT were 60.4 and 56.8% (<i>P</i> < 0.0001) and specificities 99.7% and 99.8% (<i>P</i> = 0.076). Sensitivity inversely correlated with rRT-PCR-Ct values. The RDTs had higher sensitivities in individuals referr2022-01-01T00:00:00Z20222025-04-04T23:34:41.081Z2025-04-04T23:34:41.081ZS-EPMC89790303538692010.3389/fmed.2022.774550