biostudies-literatureUnknown12(4)Walecka-Kurczyk AHere, we report a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produced the products in excellent yields above 90%.RSC advances2107-2114https://www.ebi.ac.uk/biostudies/studies/S-EPMC8979322biostudies-literatureNon-Kolbe electrolysis of <i>N</i>-protected-α-amino acids: a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines.PMC8979322Walecka-Kurczyk AWalczak KMichalak MPazdzierniok-Holewa AAdamek JfalseNon-Kolbe electrolysis of <i>N</i>-protected-α-amino acids: a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines.Here, we report a standardized method for the synthesis of <i>N</i>-protected (1-methoxyalkyl)amines by the electrochemical decarboxylative α-methoxylation of α-amino acid derivatives using the commercially available, easy-to-use, compact ElectraSyn 2.0 setup. The use of equipment with a standardized power source, electrodes, and other accessories allows this experimental procedure to be easily transferred to any laboratory in the world. A simple workup and chromatography-free purification produced the products in excellent yields above 90%.2022-01-01T00:00:00Z2022 Jan2025-04-04T23:16:37.922Z2025-04-04T23:16:37.922ZS-EPMC89793223542522410.1039/d1ra08124a