biostudies-literatureLecouturier JNational Institute for Health Research (NIHR)e0265048https://www.ebi.ac.uk/biostudies/studies/S-EPMC8979436biostudies-literatureUnknown17(4)<h4>Objectives</h4>Cutaneous melanoma rates are steadily increasing. Up to 20% of patients diagnosed with AJCC Stage I/II melanomas will develop metastatic disease. To date there are no consistently reliable means to accurately identify truly high versus low-risk patient subpopulations. There is hence an urgent need for more accurate prediction of prognosis to determine appropriate clinical management. Validation of a novel prognostic test based on the immunohistochemical expression of two protein biomarkers in the epidermal microenvironment of primary melanomas was undertaken; loss of these biomarkers had previously been shown to be associated with a higher risk of recurrence or metastasis. A parallel qualitative study exploring secondary care health professional and patient views of the PloS oneHealth professional and patient views of a novel prognostic test for melanoma: A theoretically informed qualitative study.PMC8979436II-LA-0417-20001Lecouturier JLabus MEllis RALovat PEBosomworth HfalseHealth professional and patient views of a novel prognostic test for melanoma: A theoretically informed qualitative study.<h4>Objectives</h4>Cutaneous melanoma rates are steadily increasing. Up to 20% of patients diagnosed with AJCC Stage I/II melanomas will develop metastatic disease. To date there are no consistently reliable means to accurately identify truly high versus low-risk patient subpopulations. There is hence an urgent need for more accurate prediction of prognosis to determine appropriate clinical management. Validation of a novel prognostic test based on the immunohistochemical expression of two protein biomarkers in the epidermal microenvironment of primary melanomas was undertaken; loss of these biomarkers had previously been shown to be associated with a higher risk of recurrence or metastasis. A parallel qualitative study exploring secondary care health professional and patient views of the 2022-01-01T00:00:00Z20222025-04-05T15:52:55.27Z2025-04-05T15:52:55.27ZS-EPMC89794363537788710.1371/journal.pone.0265048