{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["42"],"submitter":["Diniz WJS"],"funding":["USDA"],"pubmed_abstract":["Fetal programming is established early in life, likely through epigenetic mechanisms that control gene expression. Micronutrients can act as epigenetic modifiers (EM) by modulating the genome through mechanisms that include DNA methylation and post-translational modification of chromatin. Among the EM, methionine, choline, folate, and vitamin B<sub>12</sub> have been suggested as key players of DNA methylation. However, the effects of supplementing these four EM, involved in the methionine folate cycle on DNA methylation, are still under investigation. This manuscript provides the genome-wide DNA methylation dataset (GSE180362) of bovine embryonic fibroblast cells exposed to different supplementation levels of glucose and methionine, choline, folate, and vitamin B<sub>12</sub> (collectivel"],"journal":["Data in brief"],"pagination":["108074"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980535"],"repository":["biostudies-literature"],"pubmed_title":["DNA methylation dataset of bovine embryonic fibroblast cells treated with epigenetic modifiers and divergent energy supply."],"pmcid":["PMC8980535"],"pubmed_authors":["Diniz WJS","Dahlen CR","Crouse MS","Ward AK","Lindholm-Perry AK","Caton JS","Reynolds LP","Claycombe-Larson KJ","Borowicz PP"],"additional_accession":[]},"is_claimable":false,"name":"DNA methylation dataset of bovine embryonic fibroblast cells treated with epigenetic modifiers and divergent energy supply.","description":"Fetal programming is established early in life, likely through epigenetic mechanisms that control gene expression. Micronutrients can act as epigenetic modifiers (EM) by modulating the genome through mechanisms that include DNA methylation and post-translational modification of chromatin. Among the EM, methionine, choline, folate, and vitamin B<sub>12</sub> have been suggested as key players of DNA methylation. However, the effects of supplementing these four EM, involved in the methionine folate cycle on DNA methylation, are still under investigation. This manuscript provides the genome-wide DNA methylation dataset (GSE180362) of bovine embryonic fibroblast cells exposed to different supplementation levels of glucose and methionine, choline, folate, and vitamin B<sub>12</sub> (collectivel","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jun","modification":"2026-04-08T17:27:57.083Z","creation":"2025-04-04T10:02:17.159Z"},"accession":"S-EPMC8980535","cross_references":{"pubmed":["35392625"],"doi":["10.1016/j.dib.2022.108074"]}}