{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gkousioudi A"],"funding":["NIA NIH HHS","NHLBI NIH HHS"],"pagination":["862996"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8980683"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by the presence of conditions associated with metabolic syndrome. In this study, we investigated the combined effects of diet-induced metabolic syndrome and aging on the biomechanical properties of mouse common carotid arteries (CCA). Male mice at 2 months of age were fed a normal or a high fat and high sucrose (HFHS) diet for 2 (young group), 8 (adult group) and 18-20 (old group) months. CCAs were excised and subjected to <i>in vitro</i> biaxial inflation-extension tests and the Cauchy stress-stretch relationships were determined in both the circumferential and longitudinal directions. The elastic energy storage of CCAs was obtained using a four-fiber family constitutive model, while the material stiffness in the circumferential and longitudinal directions was computed. Our study showed that aging is a dominant factor affecting arterial remodeling in the adult and old mice, to a similar extent, with stiffening manifested with a significantly reduced capability of energy storage by ∼50% (<i>p</i> < 0.05) and decreases in material stiffness and stress (<i>p</i> < 0.05), regardless of diet. On the other hand, high fat high sucrose diet resulted in an accelerated arterial remodeling in the young group at pre-diabetic stage by affecting the circumferential material stiffness and stress (<i>p</i> < 0.05), which was eventually overshadowed by aging progression. These findings have important implications on the effects of metabolic syndrome on elastic arteries in the younger populations."],"journal":["Frontiers in bioengineering and biotechnology"],"pubmed_title":["Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging."],"pmcid":["PMC8980683"],"funding_grant_id":["R01 AG062515","R01 HL136311"],"pubmed_authors":["Wainford RD","Qian J","Seta F","Gkousioudi A","Ferruzzi J","Zhang Y","Yu X"],"additional_accession":[]},"is_claimable":false,"name":"Biomechanical Properties of Mouse Carotid Arteries With Diet-Induced Metabolic Syndrome and Aging.","description":"Metabolic syndrome increases the risk of cardiovascular diseases. Arteries gradually stiffen with aging; however, it can be worsened by the presence of conditions associated with metabolic syndrome. In this study, we investigated the combined effects of diet-induced metabolic syndrome and aging on the biomechanical properties of mouse common carotid arteries (CCA). Male mice at 2 months of age were fed a normal or a high fat and high sucrose (HFHS) diet for 2 (young group), 8 (adult group) and 18-20 (old group) months. CCAs were excised and subjected to <i>in vitro</i> biaxial inflation-extension tests and the Cauchy stress-stretch relationships were determined in both the circumferential and longitudinal directions. The elastic energy storage of CCAs was obtained using a four-fiber family constitutive model, while the material stiffness in the circumferential and longitudinal directions was computed. Our study showed that aging is a dominant factor affecting arterial remodeling in the adult and old mice, to a similar extent, with stiffening manifested with a significantly reduced capability of energy storage by ∼50% (<i>p</i> < 0.05) and decreases in material stiffness and stress (<i>p</i> < 0.05), regardless of diet. On the other hand, high fat high sucrose diet resulted in an accelerated arterial remodeling in the young group at pre-diabetic stage by affecting the circumferential material stiffness and stress (<i>p</i> < 0.05), which was eventually overshadowed by aging progression. These findings have important implications on the effects of metabolic syndrome on elastic arteries in the younger populations.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-05T15:53:23.901Z","creation":"2025-04-05T15:53:23.901Z"},"accession":"S-EPMC8980683","cross_references":{"pubmed":["35392404"],"doi":["10.3389/fbioe.2022.862996"]}}